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L-leucine, beta-hydroxy-beta-methylbutyric acid (HMB) and creatine monohydrate prevent myostatin-induced Akirin-1/Mighty mRNA down-regulation and myotube atrophy
Myostatin GDF8 Akirin-1
2015/7/29
After four days of differentiation, myotubes were treated with MSTN (10 ng/ml) for two additional days and four treatment groups were studied: 1) 3x per day 10 mM Leu, 2) 3x per day 10 mM HMB, 3) 3x p...
Co-ingestion of carbohydrate and whey protein isolates enhance PGC-1α mRNA expression: a randomised, single blind, cross over study
Muscle protein synthesis Protein supplementation
2015/7/27
Whey protein isolates (WPI) supplementation is known to improve resistance training adaptations.
However, limited information is available on the effects of WPI plus carbohydrate (CHO) supplementatio...
通过给SD大鼠注射AMPK激动剂AICAR，提高大鼠骨骼肌中AMPK的活性，探讨AMPK活性变化对骨骼肌蛋白质降解的作用。采用同位素技术测定腓肠肌中AMPK活性的变化；采用实时荧光定量PCR技术，测定腓肠肌中MuRF1、MAFbx基因表达量的变化。结果显示AICAR注射后1、2、7 h，AMPK活性与对照组相比升高，差异有显著性或非常显著性意义(P<0.05或P<0.01)；AICAR注射后7 h...