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Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
autocrine signaling bone marrow cells breast cancer
2014/11/6
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB...
The effects of environmental disturbances on tumor growth
tumor cell growth model noise interference steady probability distribution
2012/5/17
In this study, the analytic expressions of the steady probability distribution of tumor cells were established based on the steady state solution to the corresponding Fokker-Planck equation. Then, the...
Competition, coexistence, and critical behaviour in a lattice tumor-growth model
Competition coexistence critical behaviour lattice tumor-growth model
2010/11/15
In the present paper we study a lattice tumor-growth model. Monte Carlo simulations for $d=$1, 2, and 3 show that when nutrients are easily available, normal and tumor cells coexist. However, when the...
Attractiveness of a positive steady state in a population tumor growth model with quiescence
Tumor growth model Lyapunov function omega limit set
2010/9/10
We are interested in the asymptotic behavior of solutions of a dynamic population tumor cells model, having a trivial and a possible nontrivial stationary equilibrium points, first proposed by Gyllenb...