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中国科学院动物研究所魏妥团队合作开发器官和细胞双重特异性mRNA靶向递送技术（图）
魏妥 器官 细胞
2024/10/19
mRNA疗法因其研发周期短、生产成本低、制备工艺简单、起效快等多种优势，已被广泛应用于疫苗研发、蛋白替代疗法和基因编辑等领域。脂质纳米颗粒（Lipid Nanoparticle，LNP）是目前递送mRNA的最佳载体之一。然而，LNP的靶向递送能力尚存在限制，其在肝脏和肌肉递送方面已取得显著进展，但对肝外器官的靶向递送仍面临挑战。此前，我们开发了一种通用的器官选择性递送策略，简称Selective ...
心肌纤维化作为心衰的重要诱导因素，是由中重度冠状动脉粥样硬化性狭窄所引起的心肌纤维持续性和反复加重的心肌缺血、缺氧病变，全球每年有数十万人死于心肌纤维化导致的疾病。既往通过CAR-T细胞治疗心肌纤维化相关疾病时，由于该细胞在体内能存活数月甚至数年并持续攻击全身范围的成纤维细胞，从而导致伤口难以愈合，这大大限制了CAR-T疗法对心肌纤维化的治疗。
2021年10月25日讯/生物谷BIOON/---在一项新的研究中，来自美国国家卫生研究院等研究机构的研究人员在恒河猴接种初始疫苗系列（primary vaccine series）大约六个月后，给它们加强注射mRNA-1273 COVID-19疫苗，可显著提高针对所有已知SARS-CoV-2变体的中和抗体水平。相关研究结果于2021年10月21日在线发表在Science期刊上，论文标题为“Pro...
2015年11月11日，国际学术期刊Cell reports 在线发表了中国科学院上海生命科学研究院营养科学研究所冯英组的最新研究进展：SRSF10 plays a role in myoblast differentiation and glucose production via regulation of alternative splicing。该研究揭示了mRNA剪接蛋白SRS...
Transcriptional Expression Profile of Toll Like Receptor 1 - 10 mRNA in Bovine Peripheral Mononuclear Cells in Response to Foot and Mouth Disease Antigens
Innate Immunity FMDV DNA Vaccine TLR Genes
2013/1/28
Toll like receptors are the primary component of innate immune response. The comparison of expression of innate immune genes TLR 1 - 10 was carried out by real time PCR by quantifying mRNA in bovine P...
观察脑通胶囊对血管性痴呆(VD)大鼠学习记忆、海马N-甲基-D-天冬氨酸(NMDA)受体及锥体细胞的影响。 方法: 随机抽取大鼠19只作为假手术组,其余采用改良的四血管法(4-VO)制备VD模型并随机分为模型组、尼莫地平组(12 mg·kg-1·d-1)、脑通胶囊高剂量组(1 200 mg·kg-1·d-1)、脑通胶囊中剂量组(600 mg·kg-1·d-1)、脑通胶囊低剂量组(300 mg·kg...
Molecular Mechanisms Regulating mRNA Stability: Physiological and Pathological Significance
mRNA stability AU-rich elements AU-binding proteins RNA interference microRNA computational biology
2009/12/24
The cytoplasmic level of a messenger RNA, and hence protein, depends not only upon its rates of synthesis,processing, and transport, but its decay rate as well. mRNA decay rates are frequently not sta...
Is Stat3 and/or p53 mRNA expression a prognostic marker for renal cell carcinoma?
Stat3 p53 mRNA cell carcinoma
2009/12/16
Signal transducer and activator of transcription (Stat) 3 and p53 integrate upstream signals, and are positive and negative regulators of tumor cell proliferation, respectively. Stat3 and p53 also neg...
Effects to amount of metallothionein and mRNA in testis by cadmium injection and oral administration to male rats
Cadmium intake Metallothionein Cadmium toxicity Testicular damage Gene expression
2009/4/1
Male Wistar rats were given cadmium by intraperitoneal (ip) injection (1mgCd/kg). Other male Wistar rats were given Cd by oral administration at a dose of 0, 1, 2, and 5 mgCd/kg/day. All rats were sla...
Effects of granisetron and vagotomy on c-fos mRNA expression in the rat medulla oblongata as assessed by in situ hybridization
granisetron c-fos mRNA expression rat medulla oblongata situ hybridization
2009/3/3
Cancer chemotherapy-induced nausea and vomiting have been demonstrated to involve humoral as well as neuronal mechanisms. A leading role of serotonin (5-hydroxytryptamine, 5-HT) in these mechanisms ...
Effect of a diode laser on cell proliferation, alkaline phosphatase activity, and osteopontin mRNA expression in proliferating and in differentiating osteoblastic cells
cell proliferation alkaline phosphatase activity osteopontin mRNA expression
2009/3/3
Different types of osteoblast behavior result from external stimulation in the early and in the late stages of cell differentiation. The purpose of this study was to investigate the influence of a d...
Evidence for inclusion of a segment of Escherichia coli genomic DNA in bovine tooth germ mRNA encoding salivary proline-rich protein P-B
Escherichia coli genomic DNA germ mRNA salivary proline-rich protein P-B
2009/3/3
In the course of cloning of bovine cDNA for proline-rich protein (PRP) P-B from bovine tooth germ cDNA, we found that one clone with 662 bp contained a 5'-terminal 393 bp (1-393 bp) sequence essenti...
Bone formation in β-tricalcium phosphate-filled bone defects of the rat femur：Morphometric analysis and expression of bone related protein mRNA
β-tricalcium phosphate-filled bone rat femur Morphometric analysis bone related protein mRNA
2009/3/2
The purpose of the current study was to evaluate the bone formation when β-tricalcium phosphate (TCP) was implanted in bone defects of rat femurs. β-TCP granules were applied to defects created in t...
The effect of magnetic stimulation on unloaded soleus muscle of rat：changes in myosin heavy chain mRNA isoforms
magnetic stimulation unloaded soleus muscle of rat myosin heavy chain mRNA isoforms
2009/3/2
This study assessed the potential application and the effectiveness of functional magnetic stimulation (FMS) for preventing skeletal muscle atrophy in adult rats. FMS using magnetic stimulator was p...
POMC and orexin mRNA expressions induced by anticipation of a corn-oil emulsion feeding are maintained at the high levels until oil ingestion
POMC orexin mRNA expressions corn-oil emulsion feeding until oil ingestion
2009/3/2
We investigated the gene expression dynamics of several hypothalamic neuropeptides associated with appetite regulation when rats are anticipating being fed a corn-oil emulsion. For 5 days at the sam...