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上海交通大学医学院附属第九医院张志愿院士团队连续2次在《Molecular Cancer》发文揭示lncRNA在头颈鳞癌致病机理中的新机制（图）
上海交通大学口腔医学院；张志愿院士；Molecular Cancer；lncRNA；头颈鳞癌
2021/9/23
头颈鳞癌是颌面部最常见的恶性肿瘤，病变造成疼痛、言语和吞咽障碍，甚至威胁生命。近20年头颈鳞癌诊疗技术不断发展，但5年生存率仅有50-60%，且术后复发、转移和放化疗耐受的问题尚未解决，由此造成的多器官功能障碍是患者死亡的主要原因，也是长久以来肿瘤治疗面临的巨大挑战。
2020年2月，中心实验室葛兮源副研究员课题组在肿瘤研究领域著名期刊Cancer Research上在线发表了题为《Long noncoding RNA MRPL23-AS1 Promotes Adenoid Cystic Carcinoma Lung Metastasis》的研究论文，揭示了一种新的长链非编码RNA MRPL23-AS1 通过与EZH2蛋白形成RNA-蛋白复合体，导致E-cadh...
Prevention and Early Detection of Oral Mucositis in a Cancer Setting
Prevention and Early Oral Mucositis a Cancer Setting
2015/3/9
Oral mucositis is a common and distressing complication for patients receiving treatment for cancer. Severe mucositis resulting in the delay or cessation of cancer treatments may jeopardise the intent...
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
autocrine signaling bone marrow cells breast cancer
2014/11/6
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB...
Activation of PI3K-AKT Pathway in Oral Epithelial Dysplasia and Early Cancer of Tongue
PI3K-AKT cDNA microarray Epithelial dysplasia Early cancer Tongue
2010/1/21
Increasingly, cancers are being diagnosed at an early stage. Leukoplakia, a precancerous lesion, progresses to cancer in 5-10% of cases. We performed genetic analysis using cDNA microarray and immunoh...
Evaluation of the quality of life of patients with oral cancer in Brazil
Quality of life Mouth neoplasms Chewing Questionnaires Brazil
2009/10/19
This study performed a field trial of a Portuguese version of the University of Washington quality of life questionnaire (UW-QOL, 3rd version), aiming at appraising its ability to identify different p...
Activation of PI3K-AKT Pathway in Oral Epithelial Dysplasia and Early Cancer of Tongue
PI3K-AKT cDNA microarray Epithelial dysplasia
2010/12/1
Increasingly, cancers are being diagnosed at an early stage. Leukoplakia, a precancerous lesion, progresses to cancer in 5-10% of cases. We performed genetic analysis using cDNA microarray and immuno...
Comparison of Salivary Cytokine Levels in Oral Cancer Patients and Healthy Subjects
Saliva Oral cancer Screening test IL-6
2010/1/20
In order to find informative salivary biomarkers specific to oral cancer we examined expression of 4 kinds of cytokine in saliva. Levels of interleukins (IL-1β, -6, -8) and osteopontin were measured b...
Comparison of Salivary Cytokine Levels in Oral Cancer Patients and Healthy Subjects
Saliva Oral cancer Screening test
2010/12/1
In order to find informative salivary biomarkers specific to oral cancer we examined expression of 4 kinds of cytokine in saliva. Levels of interleukins (IL-1β, -6, -8) and osteopontin were measured b...