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Lack of association between TLR4 polymorphism and severe gram-negative bacterial infection in neonates
Neonate TLR4 gram-negative infections
2009/7/6
Aim: Gram-negative microorganisms are responsible for a significant percentage of systemic bacterial infections in neonates, which tend to progress to sepsis. Toll-like receptor 4 (TLR4), one of the ...
IL-12B Promoter Polymorphism Associated with Asthma and IL-12B Transcriptional Activity
asthma IgE interferon-gamma interleukin-12B promoter polymorphism
2010/11/22
Background: The interleukin-12B gene (IL-12B) encodes the p40 chain of interleukin-12 (IL-12), which promotes cell-mediated Th1 responses and the production of interferon-gamma (IFN-γ) that downregula...