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Spontaneous production of interleukin-5 and its heterogeneous effect on eosinophils in an adult T-cell leukemia patient
adult T-cell leukemia eosinophil heterogeneity interleukin-5
2010/11/25
We examined the functional heterogeneity of eosinophils from an adult T-cell leukemia (ATL) patient with eosinophilia. A 63-year-old man was admitted to our hospital because of lymphadenopathy. The le...
Interleukin-4 is involved in allergen-induced airway eosinophilic inflammation and bronchial hyperresponsiveness independent of genetic background
bronchial hyperresponsiveness eosinophils IgE interleukin-4 mice
2010/11/26
The role of interleukin (IL)-4 in the development of allergen-induced airway inflammation and bronchial hyperresponsiveness (BHR) is still controversial. To investigate the role of IL-4 in the develop...
Interleukin-10 inhibits the production of inflammatory cytokines by antigen-stimulated mononuclear cells from asthmatic patients
bronchial asthma granulocytemacrophage colony stimulating factor interferon-γ interleukin-1β interleukin-2 interleukin-5 interleukin-10
2010/11/25
Bronchial asthma, characterized by chronic airway inflammation, involves many inflammatory cytokines. Interleukin (IL)-10 is a potent inhibitor of cytokine synthesis. Thus, the effects of IL-10 were e...
Low-dose exogenous interleukin (IL)-12 enhances antigen-induced interferon-γ production without affecting IL-10 production in asthmatics
bronchial asthma Dermatophagoides farinae interferon-γ interleukin-10 interleukin-12 peripheral blood mononuclear cells
2010/11/25
The production of IFN-γ by PBMC was significantly enhanced by incubation with IL-12 in both patient groups (P < 0.05), while IL-12 did not affect the production of IL-10 in either group. Lymphocyte pr...
The Role of Interleukin-9 in Asthma
airway hyperresponsiveness asthma interleukin-9 interleukin-9 receptor mucus overproduction
2010/11/19
Interleukin (IL)-9 is a pleiotropic Th2 type cytokine which has been shown to play an important role in the pathogenesis of bronchial asthma. This review will concentrate on the structure, the source,...
Recurrent Non-Typhoidal Salmonella Bacteremia in a Patient with Interleukin -12p40 Deficiency
Immunologic Deficiency Syndromes Interleukin-12 Iran
2010/2/8
The South eastern region of Iran is an endemic area for salmonellosis. Sometimes bacteremia due to nontyphoidal salmonella occurs but certain patients are at increased risk for recurrent bacteremia. T...