搜索结果: 1-8 共查到“基础医学 kinase”相关记录8条 . 查询时间(0.062 秒)
IFN-g-Mediated Transcriptional Induction of the IDO (Indolamine 2,3-Dioxygenase) Gene Requires Activity of p68/PKR Protein Kinase
IFN p68/PKR IDO transcription
2009/6/26
We investigated whether the activity of double-stranded RNA activated kinase (p68/PKR) is necessary for induction of IDO (indolamine 2,3 -dioxygenase) gene by IFN-g. For this purpose, we planned to ab...
目的：探讨血管生成素-1（Ang-1）对人脐静脉内皮细胞（HUVECs）内游离镁离子浓度（［Mg2+］i）的调节机制。方法:我们采用荧光指示剂mag-fura-2，运用PTi 阳离子测定系统动态测HUVECs的［Mg2+］i。结果:Ang-1诱导的［Mg2+］i增加与细胞外Mg2+浓度无关。Ang-1诱导的［Mg2+］i增加与细胞内Ca2+浓度无关。经酪氨酸激酶阻断剂(tyrphostin A23...
Role of Protein Kinase C in Eosinophil Function
eosinophils PKC inhibitors PKC isoform protein kinase C (PKC) signal transduction
2010/11/19
Protein kinase C (PKC) isoforms are being elucidated as an increasingly diverse family of enzymes involved in the downstream signal transduction and cell function in various types of cells. To date, 1...
β2 Integrin-dependent tyrosine phosphorylation of proline-rich tyrosine kinase 2 in platelet-activating factor-activated eosinophils
degranulation eosinophil β2 integrin PYK-2 tyrosine phosphorylation
2010/11/26
Platelet-activating factor (PAF) can activate various cellular functions, including degranulation in eosinophils. In the present study, we examined tyrosine phosphorylation of intracellular proteins i...
Production of Matrix Metalloproteinases in Human Cultured Mast Cells: Involvement of Protein Kinase C—Mitogen Activated Protein Kinase Kinase—Extracellular Signal-regulated Kinase Pathway
human cultured mast cells matrix metalloproteinase-9 membrane type matrix metalloproteinase tissue inhibitor of metalloproteinase-1 tissue inhibitor of metalloproteinase-2
2010/11/18
We detected the de novo synthesis of MMP-9 in HCMC after stimulation with PMA and found that the synthesis was mediated through protein kinase C—mitogen activated protein kinase kinase (MEK)—ERK pathw...
Mechanical strain-induced DNA synthesis and cell proliferation in human airway smooth muscle cells through extracellular signal-regulated kinase
airway smooth muscle cell extracellular signal-regulated kinase mechanical strain
2010/11/25
An increased airway muscle content is one of the characteristic features of airway remodeling. Proinflammatory substances, growth factors and mechanical strain promote airway muscle cell proliferation...
T cell signaling: Protein kinase Cθ, the immunological synapse and characterization of SLAT, a novel T helper 2-specific adapter protein
immune synapse protein kinase Cθ SLAT T cell receptor CD28 Th2
2010/11/24
Triggering of the antigen-specific T cell receptor (TCR) can lead to various functional outcomes, such as activation and proliferation, anergy or cell death. This differential signaling is mainly dete...
Screening of the Bruton Tyrosine Kinase (BTK) Gene Mutations in 13 Iranian Patients with Presumed X-Linked Agammaglobulinemia
Agammaglobulinaemia Tyrosine Kinase Bruton's Tyrosine Kinase Iran X-linked Genetic Disease
2010/2/9
X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the Bruton tyrosine kinase (Btk) gene. In order to identify the mutations in Btk gene in Iranian patients with antibody ...