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Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production: Comparative study of single- and bisexual infection of Schistosoma mansoni in vivo
Schsitosoma mansoni Immunoregulation
2010/12/10
Immunobiological roles of schistosome eggs during murine experimental infection were investigated with special reference to the induction of basophilic leukocytes. After single- or bisexual infection ...
Antigen-Induced Expression of CD203c on Basophils Predicts IgE-mediated Wheat Allergy
basophil activation test CD203c omega-5 gliadin wheat allergy
2010/11/16
All wheat proteins induced concentration-dependent enhancement of CD203c expression in WA, but did not in TW. The analysis of receiver operating characteristics (ROC) showed that nOG5-induced CD203chi...
Basophils and mast cells are major players in the progression of allergic disorders. Although both cell types originate from hematopoietic stem cells, their lineage commitment pathways and mechanisms ...
New Insights into the Roles for Basophils in Acute and Chronic Allergy
allergic inflammation anaphylaxis basophils IgE IgG
2010/11/16
Basophils represent less than 1% of peripheral blood leukocytes. They are often recruited to the site of allergic inflammation, albeit in small numbers. However, it remained uncertain whether basophil...
Human Basophils and Cytokines/Chemokines
allergy basophils cell activation chemokines cytokines human
2010/11/16
Basophils comprise the smallest population in human peripheral blood leukocytes. The role of basophils in the pathogenesis of allergic diseases has long been obscure, although their accumulation and a...
Applying Surface Plasmon Resonance to Monitor the IgE-Mediated Activation of Human Basophils
basophil biosensor histamine release IgE surface plasmon resonance
2010/11/17
When basophils were sensitized with antigen specific IgE, they immediately caused the increase of resonance angle (AR) in response to either anti-IgE antibody or corresponding antigens, even when they...
Roles of IL-18 in Basophils and Mast Cells
basophils IL-18 mast cells nematode infection Th2 cytokines
2010/11/18
Basophils and mast cells are effecter cells in allergen/IgE-mediated immune responses. They induce type 1 immediate immune response in airway or other organ, resulting in bronchial asthma and other al...
Basophils: A Potential Liaison between Innate and Adaptive Immunity
adaptive immunity basophils IL-4 innate immunity parasites
2010/11/18
Activation of innate immunity is closely associated to development of protective adaptive immune response. Significant advances have been made to reveal such links between innate immunity and Th1 type...