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New method tracking changes in blood vessels could advance brain disease detection（图）
血管变化 脑部疾病 成像技术 神经退行性疾病
2023/6/26
A new imaging technique opens a path toward long-term study of blood vessels in aging brains and could help predict neurodegenerative diseases decades before symptoms begin.
Terence D. Capellini has been interested in how joints work for almost three decades. Part of it is due to personal experience, as he suffered several joint injuries as a college ice hockey player and...
Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults
cardiometabolic risk cerebrovascular disease choline older adults magnetic resonance imaging nutrition
2018/11/14
Background: There is a potential role of choline in cardiovascular and cerebrovascular disease through its involvement in lipid and one-carbon metabolism.
2017基心血管疾病RNA方法Keystone Symposia （2017 Keystone Symposia on RNA-Based Approaches in Cardiovascular Disease）
2017 基心血管疾病RNA方法 Keystone Symposia
2017/2/13
Cardiac diseases are the leading cause of death worldwide. RNA-based mechanisms and therapeutic approaches are emerging fields in cardiovascular science. This meeting will present and discuss latest d...
2017代谢和疾病的脂代谢和生物活性脂质 Keystone Symposia（2017 Keystone Symposia on Lipidomics and Bioactive Lipids in Metabolism and Disease）
Metabolism Disease
2017/1/17
The meeting will begin on Sunday, February 26 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, March 2 with a closi...
Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study
Alzheimer disease apolipoprotein E4 cholesterol cognitive function,
2018/11/12
Background: There is little information about the associations of intakes of cholesterol and eggs, a major source of dietary cholesterol, with the risk of cognitive decline in general populations or i...
Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction
obesity liver steatosis insulin resistance intestinal permeability gut barrier
2018/11/12
Background: Obesity and associated metabolic disorders are related to impairments of the intestinal barrier.
Objective: We examined lactulose:mannitol (Lac:Man) permeability in obese individuals with...
Vitamin B-6 catabolism and long-term mortality risk in patients with coronary artery disease
biomarker coronary artery disease inflammation mortality vitamin B-6
2018/11/30
Background: Low vitamin B-6 status has been related to increased risk of coronary artery disease (CAD), which is a condition that is associated with inflammation. The most common status marker, plasma...
Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease
COPD arginine citrulline nitric oxide protein breakdown
2018/11/30
Background: Chronic obstructive pulmonary disease (COPD) is a condition characterized by systemic low-grade inflammation that could increase the production of nitric oxide (NO), of which arginine is t...
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level
fatty liver gene expression liver injury metabolomics transaminases
2018/11/27
Background: Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental cha...
Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study
Mediterranean diet coronary artery disease olive oil phenolics proteomic biomarkers
2018/12/19
Background: Olive oil (OO) consumption is associated with cardiovascular disease prevention because of both its oleic acid and phenolic contents. The capacity of OO phenolics to protect against low-de...
Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis
palmitoleic fatty acid VLDL triacylglycerol biomarker lipogenesis stearoyl-CoA desaturase
2018/12/19
Background: Biochemical evidence has linked the coordinate control of fatty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). The ratio of 16:1n–7 to 16:0 [SCD1(16)] in plasma...
Lipids in Health and Disease is an Open Access, peer-reviewed, online journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease...
Alzheimer’s Disease: Genes, Proteins, and Therapy
Alzheimer’s Disease Genes Proteins Therapy
2014/3/31
Few subjects in biomedicine have aroused the interest of the scientific and lay communities alike as has Alzheimer’s disease (AD). The dramatic rise in life expectancy during the 20th century, from ro...
Importance of n23 fatty acids in health and disease
n23 Fatty acids docosahexaenoic acid, atherosclerosis coronary heart disease inflammatory diseases behavioral disorders
2016/6/3
In the past 2 decades, views about dietary n23
fatty acids have moved from speculation about their functions to
solid evidence that they are not only essential nutrients but also
may favorably modu...