搜索结果: 1-15 共查到“多肽与蛋白质生物化学 cell”相关记录27条 . 查询时间(0.224 秒)
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2023年12月,Cell期刊发布了“Best of Cell 2023”收藏专刊,评选出2022年底到2023年底期间发表在期刊中的2篇Reviews、9篇Articles、2篇Perspectives、1篇Snapshot,作为这一年中最令人兴奋的研究。中国科学院遗传与发育生物学研究所高彩霞团队于2023年6月发表的Cell文章入选该专刊中9篇年度最佳研究论文。
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近日,云南大学生物医药研究院陈大华教授和中国科学院动物研究所孙钦秒研究员受邀在Cell Press细胞出版社期刊Trends in Cell Biology发表了题为“Argonaute-dependent ribosome-associated protein quality control”的综述。该论文全面总结了核糖体相关蛋白质量控制(ribosome-associated protein ...
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浙江大学生命科学研究院2022年3月28日朱永群实验室在Cell Host & Microbe合作发文揭示新冠VOCs的单克隆抗体35B5中和Omicron的作用机制(图)
朱永群 单克隆抗体 毒株奥密克戎 蛋白 突变
2022/10/25
自去年11月份被发现以来,SARS-CoV-2 超级毒株奥密克戎(Omicron)迅速在全球传播并逐步取代了先前的受关注突变体(Variants of Concern, VOCs),该毒株在Spike蛋白中有30多个突变,使其能够逃避多数治疗性中和抗体以及一些疫苗的免疫疫。因此,开发针对Omicron的强效中和抗体,具有重要临床意义。
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2022年3月23 日,Molecular Cell在线发表了云南大学生物医药研究院陈大华团队完成的关于AGO蛋白调控新生多肽泛素化的最新研究论文。该研究详细阐述了AGO蛋白在内质网上发生相分离并且招募E3泛素连接酶Ltn1来参与新生多肽泛素化的调控。
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Protein controlled by both light and temperature can inform cell signal pathways(图)
蛋白质 细胞 信号通路
2023/7/12
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植物蛋白有利于降低心脑血管疾病相关的死亡率,但是其作用机制尚不清楚。团队选择大米、燕麦、大豆、豌豆四种植物蛋白,鸡肉作为白肉蛋白,牛肉和猪肉作为红肉蛋白,对比分析不同种类蛋白质对于高胆固醇血症地鼠血清脂质和肠道菌群的影响。选用广泛消费的猪肉蛋白和新兴的豌豆蛋白进行对比分析改善胆固醇代谢的作用机制,设计了运用抗生素消除主要肠道菌群后动植物蛋白降血脂作用效果的差异,验证是否通过肠道菌群起作用。进一步将...
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中心体是动物细胞内高度保守的细胞器,由两个互相垂直的中心粒(centriole)以及围绕在中心粒周围的外周物质(pericentriolar material,PCM)组成。中心体作为细胞内主要的微管组织中心,在细胞增殖过程中介导纺锤体的装配和染色体的分离。同时,其核心组分中心粒还能作为基体装配纤毛和鞭毛,对细胞运动与信号转导至关重要。中心体异常往往与肿瘤、小脑畸形以及纤毛病等多种人类疾病密切相关...
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浙江大学医学院段树民院士团队Cell Research发文报道溶酶体蛋白酶cathepsin D具有pH及构象依赖的双重酶活性(图)
浙江大学医学院 段树民院士 Cell Research 溶酶体蛋白酶 cathepsin D pH 构象依赖 双重酶活性
2021/2/4
溶酶体中存在多种负责降解多肽或蛋白质的蛋白水解酶。为确保它们在特定部位与环境发挥催化作用、避免“滥杀无辜”,蛋白水解酶通常以酶原的形式在囊泡内大量储存。在传统认识中,酶原是不具有催化活性的前体蛋白。然而,酶原在功能上真的只是“沉默的大多数”吗?
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期,中科院合肥研究院健康与医学技术研究所戴海明研究员与美国梅奥诊所孟学伟博士及Scott H. Kaufmann教授应邀在Cell Chemical Biology上发表题为“Selective Inhibition of BFL1: It’s All about Finding the Right Partner”评论文章,评述了丹娜法伯癌症研究所Harvey等研究人员发现的抗凋亡蛋白BFL1的...
E-Cadherin Tethered to Micropatterned Supported Lipid Bilayers as a Model for Cell Adhesion
E-Cadherin Tethered Micropatterned Lipid Bilayers Cell Adhesion
2016/5/24
Cell-cell adhesion is a dynamic process requiring recruitment, binding, and reorganization of signaling proteins in the plane of the plasma membrane. Here, we describe a new system for investigating h...
Cell adhesion to protein-micropatterned-supported lipid bilayer membranes
micropatterning microcontact printing of proteins supported lipid bilayers cell adhesion endothelial cells
2016/5/23
A new method for constructing controlled interfaces between cells and synthetic supported lipid bilayer membranes is reported. Microcontact printing is used to define squares and grid lines of fibrone...
Inhibiting protein clearance to induce cell death in tuberous sclerosis and pancreatic cancer
Ral 4-phenylbutyric acid 4-PBA
2015/5/25
Sequestration at the aggresome and degradation through autophagy are two approaches by which a cell can counteract the toxic effect of misfolded proteins. Tuberous sclerosis (TS) and cancer cells can ...
B cell development and immunoglobulin genes in cattle
Cellular immune globulin genes immune system lymphoid tissue immunoglobulin molecules
2014/12/11
The objective of this dissertation was to study B cell development and the mechanism of immunoglobulin gene diversification in cattle. The bovine immune system differs from that of the mouse and human...
Follicle cell calmodulin: transcript accumulation in vitellogenic follicles of {\it Blattella germanica\/} is regulated by juvenile hormone
Calmodulin cells calmodulin oocytes vitellogenesis early embryo
2014/12/11
Calmodulin (CaM) is a major intracellular calcium receptor. There is abundant calmodulin (CaM) in the oocytes and eggs of B. germanica during vitellogenesis and early embryogenesis. The accumulation o...
The influence of WC1 isoforms on gammadelta T cell function
Scavenger receptor WC1 molecules diversity rich cysteine membrane surface glycoprotein T cells
2014/12/11
WC1 molecules are an extensively diversified family of integral type 1 scavenger receptor cysteine rich (SRCR) membrane glycoproteins expressed on the surface of arteriodactyls such as sheep, cattle, ...