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中国科学院瘤内基因编辑增效ACT疗法研究获进展（图）
瘤内基因 编辑增效 ACT疗法
2023/5/18
过继T细胞转移（adoptive T-cell transfer，ACT）疗法是颇具前景的肿瘤免疫疗法，但对实体瘤效果欠佳，亟需通过学科交叉来发展针对实体瘤增效的新理念和新技术。近日，中国科学院过程工程研究所生化工程国家重点实验室研究员魏炜团队与浙江大学药学院教授平渊团队交叉合作，通过非侵入手段激活实体瘤的基因编辑，同时调控实体瘤物理和免疫微环境，显著提升了多种ACT疗法对实体瘤的疗效。相关研究成...
中国科学院过程工程研究所在瘤内基因编辑增效ACT疗法研究方面取得新进展（图）
瘤内 基因编辑 增效ACT疗法
2023/5/19
过继T细胞转移（adoptive T-cell transfer，ACT）疗法是极具前景的肿瘤免疫疗法，但对实体瘤效果欠佳，亟需通过学科交叉来发展针对实体瘤增效的新理念和新技术。近日，过程工程所生化工程国家重点实验室与浙江大学药学院交叉合作，通过非侵入手段激活实体瘤的基因编辑，并同时调控实体瘤物理和免疫微环境，显著提升了多种ACT疗法对实体瘤的疗效。相关工作发表于Nature Nanotechno...
Plants Under Heat Stress Must Act Surprisingly Quickly to Survive（图）
Plants Under Heat Stress Quickly to Survive
2017/9/5
In new results reported in The Plant Cell, molecular biologist Elizabeth Vierling at the University of Massachusetts Amherst and colleagues in India and China report finding a crucial mechanism that p...
The concept that biodiversity feeds upon itself is an old idea, but it’s difficult to prove because it requires biologists to simultaneously catch several species red-handed just as they are becoming ...
Death associated lepidopteran DALP, and its mammalian ortholog Hic-5, act as negative regulators of muscle differentiation
Vertebrates muscle differentiation muscle cells trunk limbs satellite cells cell apoptosis molecular regulation gene
2014/12/11
During muscle differentiation in vertebrates, myoblasts initially form in somites and then migrate to proper locations in the trunk and limbs. Once there, these cells are faced with one of three choic...
Ecological balancing act（图）
Phytoplankton diversity Ecological balancing act the ocean’s physical dynamics
2010/3/24
Phytoplankton are single-celled organisms that serve as the base of the marine food web and provide half the oxygen we breathe on Earth. They also play a key role in global climate change by removing ...
摘要 通过连续四天腹腔给硒(1μgNa_2SeO_3/克体重)后,腹水型肝癌细胞中与细胞分化相关的CPS_(ase)Ⅰ活性显著上升,同时与细胞增殖相关的ACT_(ase)活性明显下降。而在正常鼠肝中,按相同方式给硒的结果是ACT_(ase)活性明显增高,CPS_(ase)Ⅰ活性则略有下降。该结果表明硒可能涉及对细胞分化与增殖的调控。