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Therapeutic brain modulation with targeted large neutral amino acid supplements in the Pah-enu2 phenylketonuria mouse model
phenylketonuria inborn error of metabolism large neutral amino acids mouse model neurotransmitters brain biochemistry treatment
2018/12/18
Background: Phenylketonuria treatment consists mainly of a Phe-restricted diet, which leads to suboptimal neurocognitive and psychosocial outcomes. Supplementation of large neutral amino acids (LNAAs)...
Transcriptome sequencing reveals both neutral and adaptive genome dynamics in a marine invader
adaptation invasive species natural selection contemporary evolution
2015/12/11
Species invasions cause significant ecological and economic damage, and genetic information is important to understanding and managing invasive species. In the ocean,
many invasive species have...
Some epidemics have been empirically observed to exhibit outbreaks of all possible sizes, i.e., to be scalefree or scale-invariant. Different explanations for this finding have been put forward; among...
Strong Noise Effects in one-dimensional Neutral Populations
Strong Noise Effects one-dimensional Neutral Populations
2011/1/5
The dynamics of well-mixed biological populations is usually studied by mean-field methods and weak-noise expansions. Similar methods have been applied also in spatially extended problems, relying on ...
The Moran model as a dynamical process on networks and its implications for neutral speciation
dynamical process networks implications
2011/1/5
In genetics the Moran model describes the neutral evolution of a bi-allelic gene in a population of haploid individuals subjected to mutations. We show in this paper that this model can be mapped into...
The bovine protein a-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress
Tryptophan a-lactalbumin serotonin, prolactin cortisol stress mood
2016/6/7
Background: Increased brain serotonin may improve the ability to
cope with stress, whereas a decline in serotonin activity is involved
in depressive mood. The uptake of the serotonin precursor, tryp...