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基于元基因组测序的微生物组功能分析和比较在疾病诊断、生态监控、生物安全等领域具有广阔应用价值，但是高昂的成本限制了其更广泛应用。日前，青岛能源所单细胞中心开发了微生物组功能校正算法Meta-Apo（Metagenomic Apochromat），为大规模的菌群功能比较提供了一种保证分析精度的同时可大幅降低实验和计算成本的解决方案。目前，微生物组功能的分析和比较，主要基于基因组序列进行代谢重建。路线...
中国科学院上海营养与健康研究所Andrew Teschendorff研究组和汪思佳研究组首次通过Meta分析阐述血液中细胞特异性的DNA甲基化改变（图）
Meta 血液 细胞特异性 DNA甲基化
2020/9/24
2020年9月22日，国际期刊Nature Communications在线发表了中国科学院上海营养与健康研究所（中国科学院-马普学会计算生物学伙伴研究所）Andrew Teschendorff课题组与汪思佳课题组合作的题为“A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific sm...
溃疡性结肠炎患者巨细胞病毒感染或再激活危险因素的Meta分析
溃疡性结肠炎 巨细胞病毒 危险因素 Meta分析
2020/3/10
探讨溃疡性结肠炎(ulcerative colitis, UC)患者发生巨细胞病毒(cytomegalovirus, CMV)感染或再激活的危险因素。计算机检索英文数据库PubMed、Cochrane、Embase及中文数据库中国知网(CNKI)、万方数据知识服务平台(Wanfang)、中国生物医学文献服务系统(SinoMed)与维普期刊资源整合服务平台(VIP)，收集2017年3月之前国内外公开...
系统评价促性腺激素释放激素类似物联合化疗治疗早期绝经前乳腺癌患者的有效性。［方法］ 数据库检索国内外1996~2018年发表的促性腺激素释放激素类似物(gonadotropin-releasing hormone analog，GnRHa)联合化疗治疗早期绝经前乳腺癌患者的前瞻性随机对照临床试验研究，对符合纳入标准的研究使用Jadad评分进行文献质量评价，并使用STATA 12.0 软件进行met...
探讨亚洲黄种人炎症性肠病（IBD）患者硫嘌呤甲基转移酶（TPMT）基因多态性与嘌呤类药物不良反应(ADR)之间的关系。方法分别以“thiopurineS-methyltransferase”、“inflammatoryboweldisease/ulcerativecolitis/crohn’sdisease”和“thiopurine/azathioprine/6-mercaptopurine”及“...
自噬相关蛋白Beclin-1在胃癌患者中表达意义的 meta 分析
自噬 Beclin-1 胃癌 meta 分析
2020/7/10
对自噬相关蛋白 Beclin-1 在胃癌组织中的表达及其与胃癌患者不同临床病理特征的相关性及其临床意义进行系统评价。方法 计算机检索 Cochrane Library、Springer Link、Web of Science、Embase、PubMed、中国知网、万方、维普等数据库建库至 2018 年 6 月 1 日前公开发表的关于胃肿瘤组织中 Beclin-1 蛋白表达及其意义的研究，由 2 名...
评价九价人乳头瘤病毒（HPV）疫苗接种后保护效果、免疫原性及安全性, 为中国HPV免疫策略制定提供循证依据。 方法 检索中国知网数据库（CNKI）、万方数据知识服务平台、维普期刊资源整合服务平台（VIP）、Medline/PubMed数据库、EMBASE数据库、Cochrane Library数据库和clinicaltrials.gov数据库，收集2018年8月31日之前公开发表的关于HPV...
A systematic review and meta-analysis of nutrition therapy compared with dietary advice in patients with type 2 diabetes
dietary advice individualized nutrition therapy meta-analysis review type 2 diabetes
2018/11/21
Background: Despite recommendations, many patients with type 2 diabetes receive dietary advice from nurses or doctors instead of individualized nutrition therapy (INT) that is provided by a dietitian.
应用Meta分析方法评价促红细胞生成素对急性心肌梗死患者经皮冠状动脉成形术后的疗效及安全性。 方法 检索中文数据库(中国知网、中国生物医学文献、万方、维普)和英文数据库(PubMed、Embase、Cochrane Library、Web of Science),时间截止至2017年1月31日。纳入有关急性心肌梗死患者经皮冠状动脉成形术后促红细胞生成素与非促红细胞生成素疗效比较的随机对照试验,采用...
Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis
elderly people obesity protein supplementation resistance exercise body composition
2018/11/16
Background: Overweight and obese older people face a high risk of muscle loss and impaired physical function, which may contribute to sarcopenic obesity. Resistance exercise training (RET) has a benef...
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies
cobalamin c.776G>C genetic association studies
2018/11/20
Background: Vitamin B-12 (cobalamin) deficiency may produce severe neurologic and hematologic manifestations. Approximately 20–25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is r...
Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis
elderly people obesity protein supplementation resistance exercise body composition
2018/11/20
Background: Overweight and obese older people face a high risk of muscle loss and impaired physical function, which may contribute to sarcopenic obesity. Resistance exercise training (RET) has a benef...
Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis
short-chain fatty acids prebiotics synbiotics C-reactive protein IL-6 TNF-α systemic inflammation humans
2018/11/19
Background: Prebiotic soluble fibers are fermented by beneficial bacteria in the colon to produce short-chain fatty acids (SCFAs), which are proposed to have systemic anti-inflammatory effects.
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone bone estrogen deficiency osteopenia osteoporosis
2018/11/19
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone, bone, estrogen deficiency, osteopenia, osteoporosis
2018/11/16
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...