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Short-Term Exercise In Mice Increases Tibial Post-Yield Mechanical Properties While Two Weeks of Latency Following Exercise Increases Tissue-Level Strength
running mechanical properties histomorphometry extracellular matrix
2014/11/6
We have previously shown that exercise during growth increases post-yield deformation in C57BL6/129 (B6;129) male tibiae at the expense of reduced pre-yield deformation and structural and tissue stren...
Exercise Alters Mineral and Matrix Composition in the Absence of Adding New Bone
Mechanical loading Mechanical properties Mineral Collagen Raman spectroscopy
2014/11/6
The mechanical properties of bone are dictated by its amount, distribution and ‘quality’. The composition of the mineral and matrix phases is integral to defining ‘bone quality’. Exercise can potentia...
Nanoscale Morphology of Type I Collagen is Altered in the Brtl Mouse Model of Osteogenesis Imperfecta
AFM nanoscale
2014/11/6
Bone has a complex hierarchical structure that has evolved to serve structural and metabolic roles in the body. Due to the complexity of bone structure and the number of diseases which affect the ultr...
Inbred Strain-Specific Response to Biglycan Deficiency in the Cortical Bone of C57BL6/129 and C3H/He Mice
inbred mice mech anical properties mCT PCR Raman histomorphometry
2014/11/6
Inbred strain-specific differences in mice exist in bone cross-sectional geometry, mechanical properties, and indices of bone formation. Inbred strain-specific responses to external stimuli also exist...
Applications of atomic force microscopy for the assessment of nanoscale morphological and mechanical properties of bone
Atomic Force Microscopy Scanning probe microscopy
2014/11/6
Scanning probe microscopy (SPM) has been in use for 30 years, and the form of SPM known as atomic force microscopy (AFM) has been around for 25 of those years. AFM has been used to produce high resolu...
Nanoscale Structure of Type I Collagen Fibrils: Quantitative Measurement of D-spacing
Collagen fibril D-spacing 2D FFT AFM
2014/11/6
This article details a quantitative method to measure the D-periodic spacing of type I collagen fibrils using atomic force microscopy coupled with analysis using a two-dimensional fast fourier transfo...
Nanoscale Changes in Collagen are Reflected in Physical and Mechanical Properties of Bone at the Microscale in Diabetic Rats
Zucker diabetic Sprague-Dawley Atomic Force Microscopy Raman Spectroscopy Reference Point Indentation D-spacing Advanced Glycation End Products
2014/11/6
Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabet...
Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties
Raloxifene mechanicaltesting toughness water
2014/11/6
Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties,...
Microcomputed Tomography Applications in Bone and Mineral Research
Bone CT Mineralization Vascularization BMD Modeling
2014/11/6
Microcomputed tomography (μCT) has evolved as a development of simple X-ray imaging into an indispensable technique used in both laboratory research and clinical diagnostics. Commercially available sy...
基于体素变化的阿尔茨海默病临床前期灰质形态学特点
磁共振成像 基于体素的形态测量学 灰质
2014/5/9
利用磁共振T1WI分组分析阿尔茨海默病(AD)的早期灰质密度的改变。方法 采用开放式系列图像研究数据库中的146例样本组成样本数据集。经跟踪,其中13例在随访过程中由AD临床前期转化为极轻度痴呆,组成"转化"(CS)组;69例始终未出现痴呆症状,组成"未痴呆"(NS)组;另以64例AD患者样本组成"痴呆"(DS)组作为对照研究。应用基于体素的形态测量学(VBM)技术观察灰质密度特征,并采用双样本t...
一种基于分段迭代的MRI成像涡流补偿方法
梯度电流 涡流补偿 累积误差 分段迭代计算
2014/10/17
在核磁共振成像中,涡流的存在会影响系统的成像质量。梯度电流预增强方法是一种被广泛采用的有效的涡流补偿方法。梯度电流预增强在一个周期内要进行上千次e指数计算,需采用快速的计算方法。迭代计算是普遍采用的涡流补偿快速计算方法,但是存在累积误差放大的问题。针对这种问题,基于迭代计算原理,我们提出了一种改进的分段迭代的MRI成像涡流补偿计算方法。实验结果表明,在计算时间同量级的条件下有效地提高了梯度预增强量...
HIFU消融治疗中监控定位的B超伪像
伪像 超声学 距离 高强度聚焦超声消融
2014/6/5
探讨HIFU消融治疗中B超伪像到探头、探头到目标组织以及治疗头到目标组织三者之间的距离关系。 方法 在不同位置固定治疗头到目标组织的距离,分别测量伪像到探头以及目标组织到探头之间的距离。 结果 伪像到探头的距离和目标组织到探头的距离之间呈线性变化关系。 结论 本实验中伪像的形成主要由B超探头引起,与治疗头的位置基本无关。
Quantitative analysis of sensor for pressure waveform measurement
sensor pressure waveform measurement
2010/2/25
In this study, we propose a quantitative analysis to evaluate the pressure waveform for locating the position and applying the appropriate force between the sensor and the radial artery. The two-axis ...
Bilateral simultaneous measurement of standing ground reaction forces in hemiparetics, below-knee amputees and healthy adults
Bilateral simultaneous measurement hemiparetics below-knee amputees healthy adults
2010/1/7
Bilateral simultaneous measurement of standing ground reaction forces in hemiparetics, below-knee amputees and healthy adults.
An experimental method for investigation of the distribution of loading forces in the human cadaver hip joint
An experimental method loading forces the human cadaver hip joint
2010/1/7
An experimental method for investigation of the distribution of loading forces in the human cadaver hip joint.