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Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model
: PTEN Hamartoma Tumour syndrome Cowden syndrome
2015/12/21
PTEN Hamartoma Tumour Syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS),
and other conditions resulting from germline mutation of the PTEN tumour suppressor gene...
Inhibitory effect of calotropis gigantea extract on ovalbumin-induced airway inflammation and arachidonic acid induced inflammation in a murine model of asthma
arachidonic acid Calotropis gigantea ovalbumin
2015/7/21
The root of Calotropis gigantea has been reported as a traditional folkloric medicine in treatment of asthma in the Indian literature. Root contain α-and β-amyrin are reported to possess anti-lipoxyge...
TLR agonists activate HPV11 E7-pulsed DCs to promote a specific T cell response in a murine model
HPV – human papillomavirus TLR – toll-like receptor DC – dendritic cell
2015/4/15
Some TLR agonists may up-regulate the activation of dendritic cells caused by viral antigenic peptides and antigen-specific cytotoxic T lymphocytes, which are crucial in HPV vaccine development. We in...
Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis
Chemokine Receptor CCR9 Rheumatoid Arthritis Inflammation Antigen-Induced Arthritis Mouse Mod-el Monocytes/Macrophages
2013/1/31
Objectives: Monocytes/macrophages accumulate in the synovial membrane in rheumatoid arthritis and play a key role in disease pathogenesis, contributing to inflammation, cartilage destruction and bone ...
Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis
Chemokine Receptor CCR9 Rheumatoid Arthritis
2013/1/31
Objectives: Monocytes/macrophages accumulate in the synovial membrane in rheumatoid arthritis and play a key role in disease pathogenesis, contributing to inflammation, cartilage destruction and bone ...
Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis
Chemokine Receptor CCR9 Rheumatoid Arthritis Inflammation Antigen-Induced Arthritis Mouse Mod-el Monocytes/Macrophages
2013/9/2
Objectives: Monocytes/macrophages accumulate in the synovial membrane in rheumatoid arthritis and play a key role in disease pathogenesis, contributing to inflammation, cartilage destruction and bone ...
A Cell Protective Mechanism in a Murine Model of Parkinson's Disease
Ramadan fasting diabetes hypertension stroke
2009/6/24
Parkinson's disease is characterized by progressive degeneration of the dopaminergic (DA) neurons in the substantia nigra (SN). However, the mechanism underlying DA cell death remains unclear. While a...
Effects of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, on Bronchial Inflammation and Remodeling in a Murine Model of Chronic Asthma
airway hyperresponsiveness airway remodeling asthma murine model PDE inhibitor
2010/11/16
Background: Phosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling.
Objective: The aim of this study was to investigate the effects of KF19514, a phosphodiesterase 4 a...
Effect of hyperbaric oxygen and penicillin in a murine model of streptococcal myositis
model hyperbaric outcomes animal mice
2009/6/5
We investigated the effect of hyperbaric oxygen (HBO2) and penicillin therapy in a murine model of group A streptococcal myositis. The thighs of mice were inoculated with Streptococcus pyogenes.
Systemic Character of Legionnaires’ Disease - A Murine Model
Legionnaires’ disease systemic disease animal model real-time polymerase chain reaction
2009/3/19
In contrast to lung infection caused by Legionella pneumophila, little is known about the pathogenesis of this disease in other organs. In this study, we analyzed the number of colony forming units (C...
A new murine model of allergic rhinitis by repeated intranasal Cry j 1 challenge
allergic rhinitis repeated intranasal Cry j 1 challenge
2009/3/2
To evaluate the long-lasting effects of new therapeutic approaches to allergies, we established a new model of allergic rhinitis by repeated challenges with intranasal Cry j 1, a common Japanese ced...
Effects of Respiratory Syncytial Virus Infection on Dendritic Cells and Cysteinyl Leukotrienes in Lung Tissues of a Murine Model of Asthma
asthma cysteinyl leukotrienes dendritic cell Dermatophagoides farinae respiratory syncytial virus
2010/11/18
Background: Pulmonary dendritic cells (DCs) play critical roles in both allergy and in viral infection. Levels of cysteinyl leukotrienes (cysLTs) increase after allergen sensitization and viral infect...
The Distinctive Effects of Acute and Chronic Psychological Stress on Airway Inflammation in a Murine Model of Allergic Asthma
airway inflammation bronchial asthma opioid psychological stress μ-opioid receptor
2010/11/18
In BALB/c mice, but not in C57BL/6 mice, the number of total cells, eosinophils and lymphocytes in the acute stress group were significantly decreased compared with those in the non-acute stress group...
Treatment of Cutaneous Leishmaniasis in Murine Model by Alcoholic Extract of Berberis vulgaris
Cutaneous leishmaniasis Treatment Berberis vulgaris Murine model
2010/2/5
In order to evaluate the effect of Berberis vulgaris extract on the experimental ulcers of cutaneous leishmaniasis (CL) on Balb/c mice, a study was undertaken over a 12 months period. Forty Balb/c mic...
Subcutaneous Vaccination of Mycobacterium bovis Bacillus Calmette-Guérin Attenuates Allergic Inflammation in a Murine Model of Asthma
asthma CD4+ T cell chemokine Mycobacterium bovis Th1/Th2
2010/11/22
We found that BCG-vaccinated mice had fewer eosinophils in BALF and less severe allergic inflammation. The expression of IL-4 as well as Eotaxin and TARC was down-regulated in the vaccinated mice, whi...