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Therapeutic brain modulation with targeted large neutral amino acid supplements in the Pah-enu2 phenylketonuria mouse model
phenylketonuria inborn error of metabolism large neutral amino acids mouse model neurotransmitters brain biochemistry treatment
2018/12/18
Background: Phenylketonuria treatment consists mainly of a Phe-restricted diet, which leads to suboptimal neurocognitive and psychosocial outcomes. Supplementation of large neutral amino acids (LNAAs)...
Alpha-Amanitin Poisoning, Nephrotoxicity and Oxidative Stress: An Experimental Mouse Model
Alpha-Amanitin Oxidative Stress Mycotoxins
2015/11/9
Background: Alpha-amanitin (α-AMA) plays a major role in Amanita phalloides poisoning, showing toxic effects on multi-organs, particularly on the liver and kidneys. Studies have shown a relationship b...
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
Fragile X mGluR MPEP audiogenic seizures open field fmr1
2015/8/3
Fragile X Syndrome is the most common form of inherited mental retardation worldwide. A Fragile X mouse model, fmr1, with a disruption in the X-linked Fmr1 gene, has three substantial deficits observe...
Developing a Mouse Model of Chronic Ankle Instability
MURINE ANKLE INJURY PHYSICAL ACTIVITY BALANCE GAIT
2017/4/19
Introduction: Ankle sprains are the most common orthopedic pathology experienced during sport and physical activity and often result in chronic ankle instability (CAI). Understanding how to prevent CA...
Nanoscale Morphology of Type I Collagen is Altered in the Brtl Mouse Model of Osteogenesis Imperfecta
AFM nanoscale
2014/11/6
Bone has a complex hierarchical structure that has evolved to serve structural and metabolic roles in the body. Due to the complexity of bone structure and the number of diseases which affect the ultr...
Effects of tissue hydration on nanoscale structural morphology and mechanics of individual Type I collagen fibrils in the Brtl mouse model of Osteogenesis Imperfecta
AFM Ultrastructure Genotype/phenotype D-periodic spacing Modulus Energy
2014/11/6
Type I collagen is the most abundant protein in mammals, and is a vital part of the extracellular matrix for numerous tissues. Despite collagen’s importance, little is known about its nanoscale morpho...
Molecular Basis and Modification of a Neural Crest Deficit in a Down Syndrome Mouse Model
Down syndrome mouse models EGCG development Dyrk1a
2015/5/22
Down syndrome (DS) is the result of trisomy of human chromosome 21 (Hsa 21) and occurs in approximately 1/700 live births. Mouse models of DS have been crucial in understanding the gene-phenotype rela...
Development of Gut Microbiota in a Mouse Model of Ovalbumin-induced Allergic Diarrhea under Sub-barrier System
Ovalbumin BALB/c mice Allergy Diarrhea Gut Microbiota
2016/5/11
This study aimed to present a mouse model of ovalbumin (OVA) induced allergic diarrhea under a sub-barrier system and investigate the development of gut microbiota in this model. Male BALB/c mice were...
Localization of the VP2 Protein of Canine Parvovirus Type 2 on the Baculovirus Envelop and Its Immunogenicity in a Mouse Model
Canine Parvovirus Type 2 VP2 Protein Baculovirus gp64 TM and CTD Subunit Vaccine
2013/2/19
In this study, the full-length VP2 gene of canine parvovirus type 2 (CPV-2) was cloned into the pBacSC vector which possesses baculovirus transmembrane domain (gp64 TM) gene, baculovirus cytoplasmic d...
Developmental Differences and Altered Gene Expression in the Ts65Dn Mouse Model of Down Syndrome
development craniofacial dysmorphology mouse model Down syndrome
2015/5/22
Trisomy 21 occurs in approximately 1 out of 750 live births and causes brachycephaly, a small oral cavity, a shortened mid-face, and mental impairments in individuals with Down syndrome (DS). Craniofa...
TGF-β Signaling May Play a Role in the Development of Goblet Cell Hyperplasia in a Mouse Model of Allergic Rhinitis
allergic rhinitis epithelial cells Smad TGF-β
2010/11/12
In the mouse model of allergic rhinitis, OVA challenge induced phosphorylation of Smad2 predominantly in epithelial cells in the nasal mucosa. In addition, the administration of an inhibitor of TGF-β ...
Adjuvant effects of Sophy β-glucan on H5N1 and H5N2 vaccination using a mouse model
β-glucan H5N1 and H5N2 vaccine Immunostimulation
2010/12/10
Sophy β-glucan, a type of β-1,3-1,6 glucan produced by a black yeast Aureobasidium pollulans strain AF0-202, is currently approved for use as a health food supplement. The new genotypic avian influenz...
A Castrated Mouse Model of Erectile Dysfunction
Penile erection castration penis androgen testosterone animal model
2008/12/19
To establish a mouse model for the study of venoocclusive erectile dysfunction, we investigated erectile function in wild-type (WT), castrated (CAST), and castrated mice receiving immediate testoste...
Measurement of Volume Changes in Mouse Spermatozoa Using an Electronic Sizing Analyzer and a Flow Cytometer: Validation and Application to an Infertile Mouse Model
Coulter counter c-ros knockout mice hypo-osmotic swelling regulatory volume decrease
2008/12/5
The importance of sperm volume has recently been highlighted in a knockout mouse model in which infertility was caused by defects in volume reguiation, which led to sperm transport failure in the fe...
An Improved Mouse Model of Atopic Dermatitis and Suppression of Skin Lesions by an Inhibitor of Tec Family Kinases
allergen atopic dermatitis mite Tec Th2
2010/11/18
We established a highly efficient, highly reproducible protocol to induce skin lesions in NC/Nga mice and successfully applied it to show the efficacy of terreic acid in treating skin lesions. This mo...