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缺血性卒中具有高发病率、高致死致残率等特点,其致病机制错综复杂,临床上防治困难,严重危害我国居民健康。阐明致病机理,对缺血神经多靶点保护、减轻“缺血瀑布”反应是未来研究神经保护药物的关键。近些年研究发现,小细胞外囊泡(small extracellular vesicles, sEVs)具有细胞主动分泌、携带蛋白质和核酸信息、在细胞之间进行信息传递的特性,不仅参与了多种疾病的发生发展进程,还因其能...
关节软骨缺损是最常见的骨科疾病之一,可引起关节功能障碍、严重疼痛和残疾,给患者个人和社会带来沉重的经济负担。不幸的是,由于软骨无神经无血管的特性,软骨缺乏自愈能力,因此关节软骨的再生仍然是一个相当大的挑战。组织工程通过理想的种子细胞、合适的生物材料和生物活性分子的结合,被认为是一种很有前途的软骨修复方法。
近日,北京友谊医院骨科中心唐海教授团队与北京邦塞科技有限公司合作在Bioactive Materials发表题为“Translation of a spinal bone cement product from bench to bedside”的研究论文。
近十几年来国内外研究发现,单纯细胞移植很难实现干细胞在脊髓复杂损伤微环境中定向分化为功能细胞。然而,组织工程策略优势在于可以根据脊髓修复的具体需求,设计支架材料、种子细胞和生物活性因子的最优组合,以应对如何重塑神经再生微环境和修复脊髓神经环路的关键科学问题。
创伤性脊髓损伤可导致脊髓组织缺损,损伤处的恶劣微环境给脊髓组织的再生以及移植细胞的存活带来巨大挑战。从在脊髓损伤处移植胚胎脊髓组织起至今近三十多年来,通过其中的胚胎脊髓神经元去替换死亡的脊髓神经元,在损伤/移植处形成神经元中继器(neuronal relay)修复脊髓损伤的理念逐渐形成,并得到了验证。然而,胚胎脊髓组织移植受到伦理学限制、移植物不易获取等多方限制,不符合临床转化的要求。如何有效地在...
Heart attacks provoke an acute immune response. Leukocytes rush to the heart muscle to remove dead cells and begin building scar tissue. This is followed by a second immune response, the resolving pha...
The Gordon Research Seminar on Natural Products and Bioactive Compounds is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to p...
Beginning with ancient traditional medicines, natural products have inspired study. Contemporary research invites collaboration across disciplines of biology, chemistry and engineering. We study the b...
Beginning with ancient traditional medicines, natural products have inspired study. Contemporary research invites collaboration across disciplines of biology, chemistry and engineering. We study the b...
The meeting will begin on Sunday, February 26 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, March 2 with a closi...
Throughout history, natural products have been an inspiration to researchers from many fields. Their complex structures have stimulated investigations into the biosynthetic pathways and provided a mot...
Because nuts have favorable fatty acid and nutrient profiles, there is growing interest in evaluating their role in a heart-healthy diet. Nuts are low in saturated fatty acids and high in monounsat...
In silico prediction methods and tools were used to determine whether bioactive peptides are hidden in the amino acid sequences of carp (Cyprinus carpio) proteins and whether they can be released afte...
Bioactive compounds and antioxidant activity of germinated mung bean, soybean and black bean sprouts were investigated to find out the effect of germination and the optimum germination time. We found ...
The quality of minced beef was improved. Combinations of modified atmosphere packaging (MAP) and vacuum packaging (VP) with lactic acid (LA), dihydroquercetin (DHQ) and linalool (LIN) mixes were used ...

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