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Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors（图）
癌细胞 选择性加载 T细胞 浸润肿瘤
2023/7/7
Checkpoint inhibitor drugs have been a gamechanger for many cancer patients. Yet around 70% don’t respond to these medications, which work by removing the “brakes” on the immune system’s response to a...
Researchers at MIT and Dana-Farber Cancer Institute have developed a new way to determine whether individual patients will respond to a specific cancer drug or not. This kind of test could help doctor...
Common feature of cancer cells may also be their Achilles' heel（图）
Common feature cancer cells Achilles' heel
2019/10/22
In a study using yeast cells and data from cancer cell lines, Johns Hopkins University scientists report finding a potential weak spot in cancer cells that have extra sets of chromosomes, the structur...
Study finds a new way to shut down cancer cells’ ability to consume glucose（图）
shut down cancer cells ability to consume glucose
2017/11/23
Cancer cells consume exorbitant amounts of glucose, a key source of energy, and shutting down this glucose consumption has long been considered a logical therapeutic strategy. However, good pharmacolo...
UA Cancer Center Team Identifies a Switch that May Help Target Dormant Cancer Cells（图）
UA Cancer Center Team Dormant Cancer Cells
2017/10/24
A study by scientists at the University of Arizona and the University of Pittsburgh may hold the key to targeting dormant — or inactive —cancer cells, which are resistant to chemotherapy and other tre...
Biomedical engineers at Duke University have discovered a way to detect signs of cancer on a cell-by-cell basis using two lasers and a camera.Several medical devices currently in use and in clinical t...
Cancer cells 'talk' to their environment,and it talks back
Cancer cells talk environment talks back
2016/11/29
Interactions between an animal cell and its environment, a fibrous network called the extracellular matrix, play a critical role in cell function, including growth and migration. But less understood i...
Two-way communication between cancer cells appears to be key to their becoming motile, clustering and spreading through metastasis, according to Rice University scientists.Members of Rice’s Cente...
EFFECTS OF CHOLINE KINASE ACTIVITY ON PHOSPHOLIPID METABOLISM AND MALIGNANT PHENOTYPE OF PROSTATE CANCER CELLS
hypoxia cancer HIF
2015/5/25
High choline uptake and increased choline kinase activity have been reported in many cancers. This has motivated the use of choline as a biomarker for tumor imaging. Tumors in general are heterogeneou...
An inhibitor of the mitotic kinase, MPS1, is selective towards pancreatic cancer cells
CIN70 MPS1 kinase inhibitor pancreatic cancer
2015/5/21
The abysmal five year pancreatic cancer survival rate of less than 6% highlights the need for new treatments for this deadly malignancy. Cytotoxic drugs normally target rapidly dividing cancer cells b...
Sound separates cancer cells from blood samples
Sound separates cancer cells blood samples
2015/4/13
Separating circulating cancer cells from blood cells for diagnostic, prognostic and treatment purposes may become much easier using an acoustic separation method and an inexpensive, disposable chip, a...
Study shows how breast cancer cells break free to spread in the body（图）
breast cancer cells break free to spread in the body
2014/12/30
A gene normally involved in the regulation of embryonic development can trigger the transition of cells into more mobile types that can spread without regard for the normal biological controls that re...
An inside job: UC-designed nanoparticles infiltrate, kill cancer cells from within（图）
cancer cells infiltrate
2014/12/1
Conventional treatment seeks to eradicate cancer cells by drugs and therapy delivered from outside the cell, which may also affect (and potentially harm) nearby normal cells.
Effects of Histone Deacetylase Inhibitors on Vitamin D Activity in Human Breast Cancer Cells
Sulforaphane histone deacetylase inhibitors vitamin D receptor
2014/11/7
Breast cancer is one of the leading causes of death in women cancer cases worldwide. Cancer is the result of environmental and genetic factors that contribute to alterations in cellular control, proli...
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
autocrine signaling bone marrow cells breast cancer
2014/11/6
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB...