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Inhibitory effect of calotropis gigantea extract on ovalbumin-induced airway inflammation and arachidonic acid induced inflammation in a murine model of asthma
arachidonic acid Calotropis gigantea ovalbumin
2015/7/21
The root of Calotropis gigantea has been reported as a traditional folkloric medicine in treatment of asthma in the Indian literature. Root contain α-and β-amyrin are reported to possess anti-lipoxyge...
The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma
Asthma Bronchoconstriction Fish Oil
2015/5/22
Asthma, a chronic inflammatory disease of the airways, affects nearly 25 million Americans. The vast majority of these patients suffer from exercise-induced bronchoconstriction (EIB), a complication o...
Exposure, sympto ms and airway inflammation among sewage workers
sewage dust endotoxins lung function nitric oxide
2010/12/22
The purpose of the study was to determine the associations between dust,endotoxins and bacterial exposure, and health effects in sewage workers. Exposure of 19 workers handling dry sludge and 25 other...
Amphiregulin Is Not Essential for Ovalbumin-Induced Acute Airway Inflammation in Mice
amphiregulin asthma EGF IgE mast cells
2010/11/12
Background: The number of amphiregulin (AR)-positive mast cells in the bronchial mucosa and the levels of AR in sputum from asthmatic patients have been reported to be increased. In addition, AR can p...
Purified Aged Garlic Extract Modulates Allergic Airway Inflammation in Balb/c Mice
Aged Garlic extract Allergic airway inflammation IFNγ IgG1 IgE Murine model
2009/12/15
Garlic is known as a potent spice and a medicinal herb with broad therapeutic properties ranging from antibacterial to anticancer and anticoagulant. Our previous studies have shown some immunoregulato...
Enhanced Goblet Cell Hyperplasia in HDC Knockout Mice with Allergic Airway Inflammation
airway remodeling asthma Gob-5 MUC5AC TNF-α
2010/11/16
The number of eosinophils in BALF increased in both the sensitized wild-type mice and Hdc-/- mice with OVA inhalation. In addition, the numbers of alveolar macrophages and lymphocytes in BALF increase...
Chemical Mediators and the Resolution of Airway Inflammation
airway inflammation asthma fish immune response lipid mediators
2010/11/17
Asthma pathobiology is remarkable for chronic airway inflammation that fails to spontaneously resolve. No curative therapy is currently available. A growing body of evidence indicates that, in health,...
Toll-Like Receptors and Airway Inflammation
airway inflammation bronchial epithelial cells innate immune
2010/11/17
The respiratory tract opens to the external environment at the oral side edge, and the other edge of the respiratory tract connects to the closed space (alveoli), and so to preserve the sterility in t...
How Early Do Airway Inflammation and Remodeling Occur?
Asthma child eosinophil neutrophil pre-school wheeze
2010/11/17
Eosinophilic airway inflammation and structural airway changes are present in school age asthmatics. When these changes occur, and their relationship, are controversial. Some structural airway changes...
Effect of Procaterol, a β2 Selective Adrenergic Receptor Agonist, on Airway Inflammation and Hyperresponsiveness
airway hyperresponsiveness allergic inflammation eosinophil murine model β2 adrenergic receptor agonist
2010/11/18
Background: β-agonists are frequently used as bronchodilators for asthma as not only a reliever but also a controller, and their utility has increased with the development of long-acting β2 selective ...
The Distinctive Effects of Acute and Chronic Psychological Stress on Airway Inflammation in a Murine Model of Allergic Asthma
airway inflammation bronchial asthma opioid psychological stress μ-opioid receptor
2010/11/18
In BALB/c mice, but not in C57BL/6 mice, the number of total cells, eosinophils and lymphocytes in the acute stress group were significantly decreased compared with those in the non-acute stress group...
Role of nitric oxide in airway inflammation and hyperresponsiveness in bronchial asthma
arginine epithelial cells inhibitory nonadrenergic non-cholinergic nerve L-NAME peroxynitrate
2010/11/26
Nitric oxide (NO) is produced within the airways and has a variety of actions on the airway function. Nitric oxide is a potent bronchodilator, and NO released from airway epithelial cells and inhibito...
Effect of a leukotriene receptor antagonist, pranlukast hydrate, on airway inflammation and airway hyperresponsiveness in patients with moderate to severe asthma
airway hyperresponsiveness airway inflammation asthma eosinophils leukotriene leukotriene receptor antagonist
2010/11/25
Asthma is characterized by chronic airway inflammation and the recruitment of inflammatory cells, typically eosinophils and lymphocytes, into the airway. Although several chemical mediators are releas...
Airway inflammation and repair in asthma
airway remodeling asthma eosinophils inflammation mast cells T cells
2010/11/25
Asthma is a disease of usually reversible airways obstruction that has prominent inflammation of the mucosa as an underlying feature. It is a disease of varying severity, with some individuals sufferi...
Effect of repeated antigen inhalation on airway inflammation and bronchial responsiveness to acetylcholine in interleukin-5 transgenic mice
bronchial hyperresponsiveness eosinophils interleukin-5 mice
2010/11/25
Bronchial hyperresponsiveness (BHR) is a characteristic feature of bronchial asthma, yet its precise mechanism remains obscure. Human studies have demonstrated that T helper 2 cytokines, including int...