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Multi-scale analysis of morphology, mechanics, and composition of collagen in murine osteogenesis imperfecta
Atomic force microscopy Raman spectroscopy Reference point indentation MicroCT crystallinity modulus
2015/1/12
Osteogenesis imperfecta is a rare congenital disease commonly characterized by brittle bones caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the...
Nanoscale Morphology of Type I Collagen is Altered in the Brtl Mouse Model of Osteogenesis Imperfecta
AFM nanoscale
2014/11/6
Bone has a complex hierarchical structure that has evolved to serve structural and metabolic roles in the body. Due to the complexity of bone structure and the number of diseases which affect the ultr...
Effects of tissue hydration on nanoscale structural morphology and mechanics of individual Type I collagen fibrils in the Brtl mouse model of Osteogenesis Imperfecta
AFM Ultrastructure Genotype/phenotype D-periodic spacing Modulus Energy
2014/11/6
Type I collagen is the most abundant protein in mammals, and is a vital part of the extracellular matrix for numerous tissues. Despite collagen’s importance, little is known about its nanoscale morpho...
Multi-scale Analysis of Bone Chemistry, Morphology and Mechanics in the oim Model of Osteogenesis Imperfecta
Atomic force microscopy Raman Spectroscopy Reference Point Indentation MicroCT Crystallinity Modulus
2014/11/6
Osteogenesis imperfecta is a congenital disease commonly characterized by brittle bones and caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the ...
Osteogenesis Imperfecta:Report of a new pedigree in Iran
Osteogenesis imperfecta Collagen anomaly Genetic disease
2010/1/6
Osteogenesis Imperfecta is a heterogeneous genetical disorder and is inherited as an autosomal dominant or autosomal recessive trait. The primary defect lies in the mutation of genes that encode type ...