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中国科学院生物物理研究所赵岩/张凯课题组与合作者揭示钠氢逆向转运蛋白NHE3-CHP1复合物自抑制调控机制的结构基础（图）
神经磷酸酶 胆汁淤积 囊性纤维化 溃疡性结肠炎 中国科学院生物物理研究所
2022/9/15
哺乳动物Na+/H+逆向转运蛋白（Na+/H+ exchangers, NHEs）属于CPA1蛋白超家族，在生物膜两侧逆向转运质子和钠离子。NHE家族介导了离子的跨膜电中性转运，在调控胞内钠离子和pH稳态中发挥着重要功能。NHE3在人的胆囊中特异性表达，与胆囊中的水和电解质的吸收，以及管腔质子分泌相关。NHE3转运活性的调控由多种信号分子和调控蛋白参与。其中，神经磷酸酶B-同源蛋白1（CHP1）是...
猪肠道钠氢交换载体(NHE3)mRNA表达的肠段特异性和发育性变化
猪 肠道钠氢交换载体 mRNA表达 肠段特异性
2009/6/11
旨在探讨猪肠道钠氢交换载体（NHE3）mRNA表达的肠段特异性和发育模式，为NHE在养猪生产中的应用提供理论依据。选取遗传背景相同的1、7、26、30、60、90和150 d蓝塘和长白公猪各5头，测体质量后屠宰，取十二指肠、空肠、回肠和结肠组织样品；以18S rRNA为内标基因，用实时荧光定量PCR法检测NHE3 mRNA在60 d长白猪表达的肠段特异性及其在蓝塘和长白猪肠道表达的发育模式。结果显...
Circadian expression of the Na+/H+ exchanger NHE3 in the mouse renal medulla
Circadian expression Na+/H+ exchanger NHE3 mouse renal medulla
2009/5/8
Renal tubular NHE3, the Na+/H+ exchanger, is a critical enzyme for electrolyte and acid-base homeostasis in the kidney. We previously demonstrated that the expression of this gene in the kidney foll...
Expression and localization of the Na+/H+ exchanger isoform NHE3 in the rat efferent ducts
Absorption fluid immunohistochemistry reverse transcription-polymerase chain reaction Western blot
2008/12/30
The efferent ducts reabsorb most of the fluid released with spermatozoa from the testis. This absorptive capacity results in a severalfold increase in sperm concentration in the proximal epididymis ...
Immunolocalization of NBC3 and NHE3 in the rat epididymis：colocalization of NBC3 and the vacuolar H+-ATPase
Immunolocalization NBC3 NHE3 rat epididymis vacuolar H+-ATPase
2008/12/25
In the male reproductive tract, the epididymis plays an important role in mediating transepithelial bicarbonate transport and luminal acidification. In the proximal vas deferens, a significant compo...
Expression and localization of the Na+/H+ exchanger isoform NHE3 in the rat efferent ducts
Expression localization Na+/H+ exchanger NHE3 rat ducts
2008/12/2
The efferent ducts reabsorb most of the fluid released with spermatozoa from the testis. This absorptive capacity results in a severalfold increase in sperm concentration in the proximal epididymis ...