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基因表达的精准调控，对机体发育和细胞的各种生理功能的维持至关重要。真核生物基因的转录主要分为转录起始（initiation）、暂停-释放（pausing-release）、延伸（elongation）和终止（termination）四个步骤，转录进程的顺利进行与DNA修饰、组蛋白修饰和RNA修饰等表观遗传修饰高度相关【1】。组蛋白修饰（histone modification）是指组蛋白在相关酶催...
LSD1-LIKE1-mediated H3K4me2 demethylation is required for homologous recombination repair
H3K4me2 genome stability LYSINE-SPECIFIC DEMETHYLASE1-LIKE1 homologous recombination
2024/2/29
Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin inhibits the progression of homologous recombination. The...