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Correlation between the Prostaglandin D2/E2 Ratio in Nasal Polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma
aspirin-intolerant asthma bronchial asthma chronic rhinosinusitis prostaglandin D2 prostaglandin E2
2010/11/17
The concentrations of PGD2 were significantly higher in the nasal polyps of the CRS-ATA group. The concentrations of PGE2 were lowest in the nasal polyps of the CRS-AIA group. The PGD2/PGE2 ratio was ...
Role of Prostaglandin D2 and Its Receptors in the Pathophysiology of Asthma
asthma CRTH2 DP eosinophils lipid mediators single nucleotide polymorphisms
2010/11/17
Prostaglandin D2 (PGD2) is one of the most abundant lipid mediators present in the airways of asthmatics. However, little was known of the role it plays in the pathophysiology of asthma, until the ide...
Prostaglandin D2 and interleukin-5 reduce CRTH2 surface expression on human eosinophils
CRTH2 eosinophils interferon-γ interleukin-4 interleukin-5 prostaglandin D2
2010/11/22
Background: Recently, a second prostaglandin D2 (PGD2) receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), was identified. Because PGD2 was reported to have chemotac...