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四川大学华西基础医学与法医学院药理学英文课件chapter10 Adrenoceptor antagonist drugs
四川大学华西基础医学与法医学院 药理学 英文课件 chapter10 Adrenoceptor antagonist drugs
2017/8/29
四川大学华西基础医学与法医学院药理学英文课件chapter10 Adrenoceptor antagonist drugs。
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
Fragile X mGluR MPEP audiogenic seizures open field fmr1
2015/8/3
Fragile X Syndrome is the most common form of inherited mental retardation worldwide. A Fragile X mouse model, fmr1, with a disruption in the X-linked Fmr1 gene, has three substantial deficits observe...
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/28
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/19
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
TNF-α Antagonist and Infection in Rheumatoid Arthritis
Inverse Probability Weighting Anti-TNF Infection Rheumatoid Arthritis
2013/1/31
Background: Anti-TNF treatment may increase infection risk, although this has been difficult to study because the timing of anti-TNF treatment is driven by disease activity, which may influence infect...
Microinjection of NMDA-type glutamate receptor agonist NMDA and antagonist D-AP-5 into the central nucleus of the amygdale alters water intake rather than food intake
NMDA受体 NMDA D-AP-5 杏仁中央核 食物摄取 水摄取
2012/6/28
目的探讨杏仁中央核中的N-甲基-D-天冬氨酸（NMDA）型谷氨酸受体对食物和水摄取的影响。方法不锈钢套管植入雄性Sprague-Dawley大鼠一侧杏仁中央核内，NMDA型谷氨酸受体激动剂原型物NMDA，或选择性NMDA受体拮抗剂D(?)-2-氨基-5-磷酰基戊酸（D-AP-5）微量注射入饱食和含水度正常的大鼠的杏仁中央核内。结果杏仁中央核内注射入8.50，17.00，或34.00 nmol NM...
Antitussive Effects of the Leukotriene Receptor Antagonist Montelukast in Patients with Cough Variant Asthma and Atopic Cough
atopic cough cough score cough variant asthma leukotriene receptor antagonist montelukast
2010/11/12
In patients with CVA, 2-week treatment with montelukast, clenbuterol, and montelukast plus clenbuterol all significantly decreased cough scores and treatment with montelukast plus clenbuterol was supe...
Synthesis and Calcium channel antagonist activity of Nifedipine analogues with Chloroindolyl substituent
Synthesis Calcium channel antagonist activity Nifedipine analogues Chloroindolyl substituent
2010/1/6
Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 were replaced by 3-chloro-1H-2-indolyl substituent, were synthesized and evaluated as calcium antagonists on ...
Interaction of different doses of Aspartame with Morphine-induced antinociception in the presence of MK-801,a NMDA antagonist
Antinociception Morphine Aspartame Sweetening agents NMDA
2010/1/4
This study was designed to investigate the relative role of sweetness and comparative effects of different taste sensation of the non - caloric sweetener , aspartame on pain and its interaction with M...
Synthesis and smooth muscle Calcium channel antagonist effect of Alkyl, Aminoalkyl 1,4-Dihydro-2,6-Dimethyl-4-Nitroimidazole-3,5 Pyridine Dicarboxylates
Ca+² channel antagonist DHP Arylpiperazine
2009/12/29
The discovery that 1,4-dihydropyridine (DHP) class of calcium channel antagonist inhibits the Ca+² influx represented a major therapeutic advance in the treatment of cardiovascular diseases such ...
Synthesis and smooth muscle Calcium channel antagonist effects of new derivatives of 1,4-Dihydropyridine containing Nitroimidazol substituent
Dihydropyridine Calcium channels antagonist GPILSM
2009/12/29
A group of racemic 3-[(2-hydroxyethyl), (2-Methoxyethyl), (2-acetylethyl) or (2-cyanoethyl)], 5- methyl, ethyl or isopropyl-1, 4-dihydro-2, 6-dimethyl-4-(1-methyl-5-nitro-2-imidazolyl)-3, 5-pyridinedi...
The effect of acute Lithium and AMI-193,a new 5HT2 antagonist,on Apomorphine-induced pecking in pigeon
Pecking Serotonin receptors Apomorphine
2009/12/24
Intramascular (IM) administration of apomorphine (a mixed D1/D2 dopamine receptors agonist 0.2-1.6 mg/kg) induced pecking, a stereotype behavior in pigeons in a dose- dependent manner. In this study t...
Synthesis and in vitro dual calcium channel antagonist-agonist activity of some 1, 4-Dihydo-2,6-dimethyl-3-nitro and cyano-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-5-pyridinecarboxylates
Calcium channel antagonist-agonist activity Dihydropyridines QSAR
2009/12/14
Background and purpose of the study: The vasorelaxant action of the dihydropyridines (DHPs) provides many useful clinical indications. However, their negative effects on cardiac contractility is still...
Effects of PAF Antagonist BN52021 on Systemic and Renal Oxidative Stress in Experimentally Induced Obstructive Jaundice
Obstructive jaundice PAF antagonist renal failure systemic stress
2009/6/29
The aim of this study is to investigate the effects of PAF antagonist BN52021 on systemic and renal oxidative stress in experimentally induced obstructive jaundice. A total of 30 Wistar-Albino type ra...
Testosterone dose-dependency of sexual and nonsexual behaviors in the gonadotropin-releasing hormone antagonist-treated male rat
Testosterone dose-dependency sexual nonsexual behaviors gonadotropin-releasing hormone male rat
2009/2/23
The testosterone dose-dependency of several mating and nonmating behaviors was examined in the male rat, chemically castrated with a GnRH antagonist analog. Graded doses of testosterone enanthate ...