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Development of transmembrane signaling in the fetal rat Leydig cell
transmembrane signaling fetal rat Leydig cell
2009/2/23
Gonadotropin binding to the adult Leydig cell activates a GTP binding protein that interacts with adenylate cyclase to increase cAMP production within the cell. The increased production of cAMP stim...
Stimulation of the proliferation and differentiation of Leydig cell precursors after the destruction of existing Leydig cells with ethane dimethyl sulphonate（EDS）can take place in the absence of LH
proliferation differentiation Leydig cell precursors
2009/2/23
In hypophysectomized rats, 2 days after the administration of the cytotoxic drug ethane dimethyl sulphonate (EDS), the proliferative activity of Leydig cell precursors increased six-fold. Thus, fact...
Leydig cell and extracellular matrix effects on Sertoli cell function：biochemical and morphologic studies
Leydig cell extracellular matrix Sertoli cell function
2009/2/23
The reciprocal influence between Leydig and Sertoli cells prepared from pig testis were studied by coculture of both types of cells in either plastic dishes or dishes coated with basement membrane...
The actions of calcitonin on the TM3 Leydig cell line and on rat Leydig cell-enriched cultures
calcitonin TM3 Leydig cell line rat Leydig cell-enriched cultures
2009/2/23
Studies demonstrating calcitonin receptors on Leydig cells have suggested that these cells may be one of the many sites affected by this peptide. To investigate this possibility, the effect of syn...
The regulation of the proliferation and differentiation of rat Leydig cell precursor cells after EDS administration or daily HCG treatment
Leydig cell Leydig cell precursor LH hCG EDS proliferation
2009/2/23
The proliferation and differentiation of possible Leydig cell precursors in adult rats were studied after destruction of the existing Leydig cells with EDS or after daily treatment with hCG. After 2...
Variation in the effect of a nongonadotropic Leydig cell stimulating factor in testicular interstitial fluid after exposure of the testis to a single episode of heat treatment
Variation nongonadotropic Leydig cell testicular interstitial fluid testis
2009/2/23
The activity of a nongonadotropic factor present in rat testicular interstitial fluid and capable of stimulating Leydig cell testosterone production was measured at intervals for 8 weeks after exp...
Follicle stimulating hormone, luteinizing hormone and testicular Leydig cell responses to estradiol immunization in Ile-de-France rams
Follicle stimulating hormone luteinizing hormone testicular Leydig cell estradiol immunization Ile-de-France rams
2009/2/23
Active immunization of Ile-de-France rams against estradiol (E2) resulted in the production of E2-neutralizing antibodies and an elevation in the plasma concentrations of FSH, LH, and testosterone...
Response to acute hCG stimulation and steroidogenic potential of Leydig cell fibroblastic precursors in humans
acute hCG stimulation steroidogenic potential Leydig cell fibroblastic precursors humans
2009/2/20
The process of early testosterone (T) secretion and Leydig cell differentiation in humans was studied to explore the steroidogenic capacity of Leydig cell fibroblastic precursors. Seven cryptorchi...
Mechanism of action of gonadotropin-releasing hormone-stimulated Leydig cell steroidogenesis. II. Gonadotropin-releasing hormone stimulates phospholipid labeling
gonadotropin-releasing hormone Leydig cells steroidogenesis phospholipids
2009/2/20
To investigate mechanisms responsible for gonadotropin-releasing hormone (GnRH)-stimulated Leydig cell steroidogenesis, the effects of GnRH agonist [des-Gly10, (D-Ala6) GnRH] on phospholipid turnove...
Mechanism of action of gonadotropin-releasing hormone-stimulated Leydig cell steroidogenesis
gonadotropin-releasing hormone Leydig cells testosterone cAMP cAMP-dependent protein kinase nifedipine calcium
2009/2/20
The present study was designed to elucidate mechanisms responsible for gonadotropin-releasing hormone (GnRH)-stimulated testosterone formation. Purified Leydig cells from adult Sprague-Dawley rats...
Physiopathologic aspects of Leydig cell function in varicocele patients
varicocele Leydig cell plasma gonadotropins
2009/2/20
Leydig cell function was studied in 108 varicocele (V) patients with a mean age of 30.9 years, and a control group (C) of 46 men with a mean age of 30 years. Plasma gonadotropin levels were determin...
The aging Leydig cell. VIII. Protein kinase activity
The aging Leydig cell Protein kinase activity
2009/2/19
The effects of aging on cyclic AMP (cAMP) dependent protein kinase activity of purified Leydig cells were evaluated. Purified Leydig cells from 20-day-, 40-day-, 60-day- and 30-month-old rats were...
Abnormalities of the Hypothalamic—Pituitary—Leydig Cell Axis in Young Adult Rats with Vitamin A Deficiency
vitamin A deficiency (VAD) hypogonadism testosterone Leydig cell hypothalamus
2009/2/19
The hypothalamic concentration of gonadotrophin releasing hormone (GnRH), the in vivo pituitary responses to GnRH, and the in vivo Leydig cell responses to bovine luteinizing hormone (LH) and to end...
Effects of the Antiestrogen CI-628 on Leydig Cell Function
testis Leydig cell estrogen receptor estradiol antiestrogens
2009/2/19
The objective of this study was to use antiestrogens as probes into the relationship between 17 -estradiol, the estrogen receptor, and Leydig cell steroidogenesis. Leydig cells purified by Metriza...
The Aging Leydig Cell: III. Gonadotropin Stimulation in Men
human aging Leydig cells testosterone 17OH-progesterone estradiol human chorionic gonadotropin
2009/2/19
To assess the capacity of aging human Leydig cells to respond to intramuscular injection of hCG, six healthy men, 68 to 86 years old, and eight healthy younger subjects, 25 to 42 years old, were s...