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Evaluation of In Vivo Transfection Efficiency of Eudragit Coated Nanoparticles of Chitosan-DNA: A pH-sensitive System Prepared for Oral DNA Delivery
Gene Therapy Delivery of DNA Nanoparticles
2015/10/22
Background: Success of any gene therapy protocol relies mostly on using an efficient carrier to direct nucleic acid to the place of action. The system should also have transfection ability at release ...
研究聚合物Eudragit RL在电解质溶液中的膨胀行为,以及介质组成及聚合物膨胀度对硝苯地平、氯苯那敏(扑尔敏)和吲哚美辛从聚合物骨架中释放的影响。用转篮法及浆板法测定微球和药膜的释放度。结果表明Eudragit RL的膨胀度随电解质浓度增加而下降,且受电解质种类的影响显著。硝苯地平和氯苯那敏从聚合物骨架中的释放速率与聚合物膨胀行为间呈良好正相关,但吲哚美辛从聚合物中的释放速率受聚合物膨胀和离子...
Determination of Compressibility and In Vitro Release Properties of Acetaminophen Granules Coated with Eudragit E 30 D
Acetaminophen Eudragit E 30 D compressibility
2009/6/22
Acetaminophen is a drug which has a bitter taste and a short biological half life (t1/2 = 2-3 hours). There are two metabolites of acetaminophen in the body. The first form is the conjugation of gluc...