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Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...
High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice
choline metabolism folic acid lipid metabolism liver methylenetetrahydrofolate reductase
2018/12/24
Background: Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are larg...
Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice
ANSERINE FATIGUE RESISTANCE FORCE–FREQUENCY RELATION CALCIUM HANDLING
2017/7/14
Purpose: Enhanced carnosine levels have been shown to be ergogenic for high-intensity exercise performances, although the role of carnosine in the control of muscle function is poorly understood. Ther...
Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice
oxide synthase overexpression mice
2014/3/31
Congestive heart failure results in cardiovascular dysfunction and
diminished vascular nitric oxide (NO) production. We hypothesized
that overexpression of endothelial NO synthase (eNOS) within the
...