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Flipping a metabolic switch to slow tumor growth（图）
Flipping metabolic switch tumor growth
2020/8/27
An enzyme can be used as a metabolically responsive "switch" that decreases tumor growth, according to a new study. The findings are published in the journal Nature.By restricting the dietary ami...
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Gene expression patterns breast carcinomas tumor subclasses clinical implications
2015/8/21
The purpose of this study was to classify breast carcinomas based on variations in gene expression patterns derived from cDNA microarrays and to correlate tumor characteristics to clinical outcome. A ...
Regulation of the p53 tumor suppressor gene in the mammary gland and its role in tumorigenesis
Biological sciences p53 Tumor suppressor Mammary gland Tumorigenesis
2015/1/28
Breast cancer is the most frequent tumor type among women. Heightened susceptibility of the breast to tumor development has been associated with early menarche, nulliparity, exposures to ionizing radi...
Hormones, growth factors, and the regulation of tumor suppressor pathways involved in parity -induced protection of breast cancer
Women with breast cancer cases diagnosis and reproduction exogenous hormones ionizing radiation genetic factors
2014/12/11
Despite current advances in understanding breast cancer, in 2007 an estimated 178,480 new cases were diagnosed in female patients in the United States, and an estimated 40,640 deaths will occur due to...
From Mouse Mammary Tumor Model to New Therapeutic Method ---Mammary Tumor Development in Balb/c-Trp53+/- Mice and Magnetic Nanoparticle Induced Heating for Cancer Treatment
Breast cancer Magnetic nanoparticle Mammary gland Mouse tumor model Stem cell Thermotherapy
2014/12/10
PATHWAYS CONTRIBUTING TO DEVELOPMENT OF SPONTANEOUS MAMMARY TUMORS IN BALB/c-Trp53+/- MICE Mutation and loss of p53 function are common features among human breast cancers. We use BALB/c-Trp53+/- mice...
Regulation and Action of Skp2 and Rhoa in Cell and Tumor Models: Investigation into the Molecular Mechanisms Responsible for the Aggressive Phenotype of Triplenegative Breast Cancer
Basal-Like Breast Cancer Cell Cycle p27 proliferation SKP2 Triple-Negative Breast Cancer
2014/12/10
Breast cancer tops the list of new cancer cases and is predicted to be the second leading cause of cancer deaths in women in 2012. The primary objective of the present study was to provide insights in...
Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in Cattle
Cattle TNFα Gene Single Nucleotide Polymorphism Milk Production Sex of Progeny
2016/5/12
In a majority of mammals, male infants have heavier body mass and grow faster than female infants. Accordingly, male offspring nursing requires a much greater maternal energy contribution to lactation...
TRP-1 AS A MODEL TUMOR ANTIGEN FOR IMMUNOTHERAPY AND IMMUNE TOLERANCE IN THE THYMUS
immune tolerance T cells mTECs
2015/5/21
Tolerance mechanisms, which collectively work to prevent autoimmunity, play a key role in suppressing the adaptive immune response to tumor antigens. This phenomenon is attributed to the extensive ove...
Quantitative model for efficient temporal targeting of tumor cells and neovasculature
Quantitative model efficient temporal targeting
2011/1/5
The combination of cytotoxic therapies and anti-angiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors. However, the timing and sequencing of these treatments ...
Computational challenges of tumor spheroid modeling
Computational challenges tumor spheroid modeling
2011/1/5
The speed and the versatility of today's computers open up new opportunities to simulate complex biological systems. Here we review a computational approach recently proposed by us to model large tumo...
Competition, coexistence, and critical behaviour in a lattice tumor-growth model
Competition coexistence critical behaviour lattice tumor-growth model
2010/11/15
In the present paper we study a lattice tumor-growth model. Monte Carlo simulations for $d=$1, 2, and 3 show that when nutrients are easily available, normal and tumor cells coexist. However, when the...
Emergent Properties of Tumor Microenvironment in a Real-life Model of Multicell Tumor Spheroids
Emergent Properties Tumor Microenvironment Real-life Model
2010/11/15
Multicellular tumor spheroids are an important {\it in vitro} model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of spheroids has...
Quantitative Trait Loci Affecting Rous Sarcoma Virus Induced Tumor Regression Trait in F2 Intercross Chickens
Chicken Quantitative Trait Locus Tumor Regression Subgroup A Rous Sarcoma Virus Non-MHC
2016/5/3
We performed a genome-wide linkage and quantitative trait locus (QTL) analysis to confirm the existence of QTL affecting Rous Sarcoma Virus (RSV) induced tumor regression, and to estimate their effect...
胞质异质性——人类肿瘤组织线粒体基因突变的普遍现象Heteroplasmy: A Common Phenomenon of Mitochondrial Genome Mutations in Human Tumor Tissues
线粒体基因 突变 异质性 同质性 肿瘤
2008/1/6
为了探讨不同肿瘤组织中线粒体基因体细胞性突变的胞质异质性和同质性状态，利用32对重叠引物对149例肿瘤组织和匹配的正常组织的全线粒体基因进行PCR扩增，并同时进行时相温度梯度凝胶电泳扫描突变筛选，基因测序确定突变类型与异质状况。结果表明，不同肿瘤组织中线粒体基因体细胞性突变的异质率不同，口腔癌（65%）和食道癌（64%）具有较高的异质率，其次为乳腺癌（45.9%）。4种转换形式的发生频率Hm→Hm...