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New method tracking changes in blood vessels could advance brain disease detection（图）
血管变化 脑部疾病 成像技术 神经退行性疾病
2023/6/26
A new imaging technique opens a path toward long-term study of blood vessels in aging brains and could help predict neurodegenerative diseases decades before symptoms begin.
近十年来，荧光激活液滴分选技术（FADS）快速发展，已成为一种强大的超高通量筛选工具，广泛应用于酶、代谢产物和抗体筛选。高灵敏度荧光偶联策略（FCSs）是FADS应用拓展的关键技术，可将酶活性、代谢产物浓度、抗体亲和力等性质与荧光信号进行偶联，实现目标物质定量检测，是FADS应用发展关键环节之一。截止目前，一系列FCSs已经被开发，极大地扩展了FADS的应用（图1）。
上海交通大学免疫学研究所李华兵等团队在Science Advance上发表新成果-揭示m6A维持肠上皮细胞稳态的功能和机制（图）
免疫学研究所 单细胞测序 肠道类器官培养 免疫荧光染色
2022/6/17
2022年3月26日，上海交通大学医学院-上海市免疫学研究所李华兵研究员团队在Science Advances杂志在线发表了题为m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated anti-apoptotic pathway的研究论文，该研究表明m6A甲基转移酶METTL14在...
NSF makes new awards to advance Science of Learning（图）
NSF new awards advance Science of Learning
2017/11/24
The National Science Foundation (NSF) has awarded $8.2 million through its Science of Learning program to fund 24 new projects that will advance theoretical insights and fundamental knowledge of learn...
Lu Develops Gene Circuit Design Strategy To Advance Synthetic Biology（图）
Lu Develops Gene Circuit Design Strategy Synthetic Biology
2017/10/24
Over the last 17 years, scientists and engineers have developed synthetic gene circuits that can program the functionality, performance, and behavior of living cells. Analogous to integrated circuits ...
NSF issues awards to advance a national research infrastructure for neuroscience（图）
NSF issues awards national research infrastructure for neuroscience
2017/9/1
The National Science Foundation (NSF) has made 17 Next Generation Networks for Neuroscience (NeuroNex) awards to aid the research community as it pursues one of its grandest challenges: understanding ...
IUPUI maps genome of black blow fly;may benefit human health,advance pest management
IUPUI genome of black blow fly benefit human health advance pest management
2016/11/29
Researchers at the School of Science at Indiana University-Purdue University Indianapolis have sequenced the genome of the black blow fly, an insect commonly found throughout the United States, southe...
Drivers performance in response to sight-limited and multi-threat crash scenarios at mid-block crosswalks: An evaluation of advance yield markings and sign prompts
Pedestrian crossing jam yields factors
2014/12/11
Mid-block crosswalks present a challenging detection task when drivers are not familiar with the area, crosswalks are at locations with high traffic volume, or the visibility of the approaching crossw...
骨形成蛋白是属于转移生长因子-β超家族生长因子的一种分泌型信号分子。迄今为止，已有30多个骨形成蛋白被确定，骨形成蛋白15基因在卵母细胞中表达，具有推动卵泡生长，阻止黄体早熟的作用。本文综述了骨形成蛋白15基因的研究现状。
Abstract:Bone morphogenetic proteins (BMPs) are secreted signalling molecules belonging...
摘要胰岛素样生长因子2在胎儿生长发育、肿瘤细胞增殖、肌肉生长等方面具有重要的调控作用。本文综述了胰岛素样生长因子2基因结构、基因组印迹和作为影响肌肉重量数量性状基因座的研究进展。Abstract: Insulin-like growth factors play an important role in fetal growth and development, tumour cell proli...
耦联性转录与翻译新进展:真核生物细胞核内的翻译The New Advance of Coupled Transcription and Translation:Translation within the Nuclei in Eukaryotes
耦联性转录与翻译 细胞核 生物素
2007/12/7
摘要原核生物转录与翻译过程是耦联的。通常认为，在真核生物中，初级转录产物经过加工和修饰成的mRNA从细胞核进入细胞质后，翻译才开始，也就是说，转录与翻译过程并不是耦联的。然而，最近Iborra 等人用赖氨酸［3H］以及生物素或BODIPY标记的赖氨酸-tRNA对哺乳动物细胞翻译位点进行定位，发现细胞核内存在耦联性转录与翻译过程，核内翻译产物占细胞总合成蛋白的10%~15%。
Abstract:I...
National Science Foundation Funding to Advance Research on Interplay Between Biology and Society（图）
biology ecology genetics
2007/7/5
June 15, 2007，Scientists will find new ways of understanding the interactions of the biological sciences with society, as a result of awards from the National Science Foundation’s (NSF) directorates f...