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2022年来HIV/AIDS老年患者数量快速增长是艾滋病防治面临的主要挑战之一,这是因为老年患者治疗后相比青年患者更难重建免疫功能而易发生其他继发性疾病,免疫衰老是其中的关键影响因素。免疫衰老是免疫系统在衰老过程中的平衡机制衰退,既会导致机体清除病原体的能力减弱,也会引发一些过激的免疫反应,这是老年人对传染性疾病更加敏感的免疫病理基础。中国科学院昆明动物研究所研究员郑永唐团队在前期研究中就已经发现...
Signal Transducer and Activator of Transcription 3 (STAT3) is known to be related to bone metabolism. Mutation of STAT3 causes a rare disorder in which serum levels of IgE are elevated. This causes va...
The essential role of Stat3 in bone homeostasis and mechanotransduction
Signal Transducer Activator of Transcription 3 Bone formation Osteoblast Osteocyte Mechanotransduction
2015/5/22
Signal Transducer and Activator of Transcription 3 (Stat3) is a transcription factor expressed in bone and joint cells that include osteoblasts, osteocytes, osteoclasts, and chondrocytes. Stat3 is act...
Bone Metabolism: The Role of STAT3 and Reactive Oxygen Species
STAT3 Bone Metabolism Reactive Oxygen Species Mitochondria
2015/5/22
Signal Transducers and Activators of Transcription 3 (STAT3), a transcription factor expressed in many cell types, including osteoblasts and osteoclasts, is emerging as a key regulator of bone mass an...