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We are pleased to announce the seventeenth biennial Neurobiology of Drosophila meeting, which will be held at Cold Spring Harbor Laboratory. The meeting will begin at 7:30 pm on the evening of Tuesday...
Regulation of programmed cell death is crucial for proper development and maintaining homeostasis of organisms. This thesis work attempts to elucidate the relationships between two evolutionarily well...
Apoptotic cell death is an important response to genotoxic stress that prevents oncogenesis. It is known that tissues can differ in their apoptotic response, but molecular mechanisms are little unders...
Genetic screens which assay behavior have been successfully used to identify genes required for neural function. This thesis is the analysis of midline uncoordinated (muc), a mutation identified for i...
The Drosophila reaper, head involution defective ( hid), and grim genes play key roles in regulating the activation of programmed cell death. In this first part of this study we use the Gal4/UAS targe...
Synaptic transmission between a neuron and its target is crucially dependent upon the precise spatial arrangement of proteins in the pre- and postsynaptic apparatus. PDZ domain-containing proteins suc...
The flow of information through neuronal circuits relies on the ability of neurons to form synaptic connections with specific temporal and spatial properties. These properties are not static but have ...
Wnt ligands are a family of highly conserved glycoproteins that act as morphogens to regulate development in many organisms. Drosophila Wnt-1 (Wingless) is involved in directing cell fate decisions an...
The ability of established synaptic connections to strengthen and weaken (synapse plasticity) underlies higher order behavior such as learning and memory. Several gaps remain in our understanding of t...
Synapses are the functional units of neuronal circuits and the sites of integration for multiple signaling pathways. Understanding the molecular basis of synaptic function is critical to understanding...
Several genes implicated in Parkinson's disease (PD) encode components of the ubiquitin-proteasome pathway. In a specific form of PD (human Autosomal Recessive Juvenile Parkinsonism, AR-JP), loss of f...
All multicellular life begins as a single cell—the fertilised egg, from which the adult organism develops. As a general priniciple, as embryos progess through development, changes in cellular status s...
The development of complex neural networks relies on a careful balance of environmental cues to guide and shape both ends of the eventual connection. However, the correct wiring of circuits whose comp...
在印度次大陆的亚热带地区,秋天冷而干燥, 春天湿润。变温性果蝇所具有的抗干燥性有助于其度过较为干旱的气候条件。 Drosophila jambulina 具有体色二型性。已有研究表明,随湿度变化, D. jambulina热带种群始终保持体色多型性, 这与热条件下体色黑化相反,且该热带物种中体色分化频率随季节性变化,这符合黑化干燥假说。但是两种色型的D.jambulina产生这类气候适应的机理尚不...
雌性对雄性表饰的偏好性有利于性别选择。目前尚不清楚这一偏好性是否只限于雄性表饰或这一偏好性实际上是源于影响后代适合度的基因。对于雄性可直接有利于雌性或其后代适合度的交配系统而言,答案是肯定的——雌性偏好于与对气候胁迫具有更强生理抗性的雄性交配。对果蝇Drosophila biarmipes 的室内研究已经证明了求偶过程中翅斑的作用,但是其生态学意义仍然不清楚。我们检验了有翅斑与无翅斑雄性果蝇D. ...

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